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RecruitingNot ApplicableNCT07331935

Efficacy of Topical Coenzyme Q10 and Curcumin for Oral Leukoplakia Treatment

Clinical and Biochemical Assessment of the Effectivness of Topical Coenzyme Q10 and Topical Curcumin in Managment of Oral Leukoplakia (A Randomized Controlled Clinical Trial)

Sponsor

Alexandria University

Enrollment

34 participants

Start Date

Nov 25, 2025

Study Type

INTERVENTIONAL

Conditions

Oral Leukoplakia

Summary

Oral leukoplakia (OL) is recognized as the most common potentially malignant disorder of the oral mucosa. The pathogenesis of OL is complex and multifactorial, with oxidative stress playing a central role. Topical antioxidants have gained attention as therapeutic options to help stabilize lesions and potentially prevent malignant transformation. Both CoQ10 and curcumin have demonstrated a clinical success as strong antioxidants showing their capacity to reduce the lesion size and to stabilize the disease, ultimately preventing progression into oral malignancy. Aim: This study aims to clinically and biochemically assess the effectiveness of topical Coenzyme Q10 and Curcumin in the management of homogeneous oral leukoplakia.

Eligibility

Min Age: 40 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether a topical (applied directly to the mouth) gel containing coenzyme Q10 and curcumin can treat oral leukoplakia — white patches in the mouth that could potentially turn into cancer. **You may be eligible if...** - You have been diagnosed with mild (homogeneous) oral leukoplakia that does not need surgery - The white patches in your mouth are accessible for applying a topical treatment - You are willing to attend follow-up appointments **You may NOT be eligible if...** - Your white patches show moderate-to-severe cell changes (dysplasia), pre-cancer, or oral cancer - You have active gum disease - You have a significant systemic illness or a weakened immune system - You are pregnant or breastfeeding - You have taken antioxidant supplements in the last four weeks Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERCoenzyme Q10 gel

Application will be performed 2-3 times daily for 4 weeks.

OTHERTopical curcumin gel

Application will be performed 2-3 times daily for 4 weeks.

Locations(1)

Outpatient Clinic of Oral medicine Department, Faculty of Dentistry, Alexandria University, Egypt

Alexandria, Egypt

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NCT07331935

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