Early General Anesthesia to Limit Experiences of Trauma During Cesarean Section-Pilot Study
EAGLET-CS Pilot: Early General Anesthesia to Limit Experiences of Trauma During Cesarean Section-Pilot Study
University of Pennsylvania
600 participants
Apr 6, 2026
INTERVENTIONAL
Conditions
Summary
Some patients who undergo cesarean section under spinal or epidural anesthesia can experience severe pain. Some patients who experience this kind of pain can experience symptoms of post-traumatic stress disorder (PTSD) after pregnancy. Currently, the two main options for treating this pain are general anesthesia (full medically induced unconsciousness) and using intravenous medications to reduce the pain and decrease anxiety. The EAGLET-CS Pilot is a pilot randomized trial that will test the feasibility of comparing the impact of these two options for preventing PTSD in a rigorous way for those patients who experience pain during their cesarean section after the baby is out.
Eligibility
Inclusion Criteria1
- Women aged 18 or older undergoing non-emergent cesarean delivery with primary neuraxial (epidural, spinal, or CSE) anesthesia. Eligible patients will be those who report severe pain during surgery, defined as pain that does not resolve with 2 trials of first-line pharmacologic therapies (e.g., epidural supplementation with local anesthetics; intravenous opioid analgesics).
Exclusion Criteria1
- We will exclude patients who require induction of general anesthesia prior to umbilical cord clamping and by clinician determination.
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Interventions
standard of care general anesthesia
standard of care intravenous anesthesia
Locations(1)
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NCT07334418