Implementation of an Algorithm- and Multi-professional Team-supported Strategy to Improve Lipid Management of Patients With Atherosclerotic Cardiovascular Disease
Implementation of an Algorithm- and Multi-professional Team-supported Strategy to Improve Lipid Management of Patients With Atherosclerotic Cardiovascular Disease: OPTIMIZE ASCVD
Colorado Prevention Center
100 participants
Dec 10, 2025
INTERVENTIONAL
Conditions
Summary
This is a randomized, controlled, collaborative, multicenter, pilot implementation science study evaluating the hypothesis that algorithm- and multi-professional team-supported lipid management reduces low density lipoprotein-cholesterol (LDL-C) compared with usual care in patients with atherosclerotic cardiovascular disease (ASCVD).
Eligibility
Inclusion Criteria8
- Provided informed consent
- Age \>18 years inclusive at screening
- Documented atherosclerotic vascular disease including:
- Coronary artery disease (prior revascularization, myocardial infarction, imaging evidence of coronary atherosclerosis)
- Peripheral artery disease (prior revascularization, amputation, ankle: brachial index (ABI) ≤ 0.90, imaging evidence of extra-coronary atherosclerosis)
- Carotid artery disease (prior endarterectomy or stenting of the extracranial carotid artery or imaging evidence of carotid atherosclerosis)
- Imaging evidence of atherosclerotic vascular disease in a non-coronary vascular bed (e.g. aorta, mesenteric, renal)
- LDL-C \>70mg/dL
Exclusion Criteria3
- Any reason that, in the opinion of the investigator, the patient would be unable to adhere to the protocol for the duration of the study (e.g. terminal diagnosis, metastatic cancer) or in whom participation might result in harm.
- Planned active titration of current lipid-lowering therapy
- Myocardial infarction or arterial revascularization within prior 30 days
Interested in this trial?
Get notified about updates and connect with the research team.
Interventions
Algorithm- and multi-professional team-supported lipid management
Guideline-directed lipid management by usual care provider
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT07334834