RecruitingEarly Phase 1NCT07337434

To Check Comparison of Apremilast and Methotrexate Efficacy in Patients With Moderate to Severe Plaque Psoriasis Presented to Tertiary Care Hospital

Comparison of Efficacy of Methotrexate vs Apremilast in Moderate to Severe Plaque Psoriasis

Sponsor

Syeda Sana Zaman

Enrollment

106 participants

Start Date

Dec 25, 2025

Study Type

INTERVENTIONAL

Conditions

Chronic plaque psoriasis

Summary

This study aims to compare efficacy of methotrexate vs apremilast in the management of chronic plaque psoriasis.Given the high prevalence of psoriasis in Pakistan and the significant psychological impact on patients, particularly in Peshawer,this study will provide valuable insights into optimal treatment strategies.

Eligibility

Min Age: 18 YearsMax Age: 60 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Apremilast and a drug called Methotrexate for people with chronic plaque psoriasis. The study is currently recruiting participants at 1 location. People eligible for this study include aged 18 Years to 60 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGMethotrexate

Group A will recieve methotrexate 10-25mg once weekly for 3 months. Along with folic acid once daily except on day of methotrexate.

DRUGApremilast

Group B will recieve tablet apremilast 30mg twice daily for 3 months.

Locations(1)

MTI-HMC Peshawar

Peshawar, Khyber Pukhtunkhwa, Pakistan

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NCT07337434