RecruitingPhase 1NCT07338266

Study to Assess the Safety and Pharmacokinetics of AVD275 Injection in Patients With Osteoarthritis of the Knee

A Single Ascending Dose Study to Assess the Safety and Pharmacokinetics of Intra-articular AVD275 Injection in Patients With Osteoarthritis of the Knee

Sponsor

Avidence Therapeutics

Enrollment

15 participants

Start Date

Jan 22, 2026

Study Type

INTERVENTIONAL

Conditions

Osteoarthritis of the knee

Summary

This study aims to understand the safety, drug concentration and distribution of an intra-articular injectable formulation of celecoxib, AVD275, in patients with knee osteoarthritis. One single injection at three different doses of the drug will be studied in a sequential order, and each participant will be monitored for 24 weeks over ten clinical visits.

Eligibility

Min Age: 20 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called AVD275 Intra-articular Injection for people with osteoarthritis of the knee. The study is currently recruiting participants at 1 location. People eligible for this study include aged 20 Years to 75 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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