RecruitingNot ApplicableNCT07344844

Adaptive Stereotactic Radiotherapy for Localized Prostate Cancer

Intérêt de la radiothérapie Adaptative en stéréotaxie Prostatique


Sponsor

Clinique Sainte Clotilde

Enrollment

100 participants

Start Date

Nov 18, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

This study evaluates whether adaptive stereotactic body radiotherapy (SBRT) provides dosimetric advantages compared to non-adaptive SBRT in localized prostate cancer. Five low-dose CT scans are performed before each SBRT session to assess anatomical variations (bladder filling, rectal volume) and determine if a dosimetric recalculation would have been required. The study also evaluates cumulative dose to organs at risk, patient-reported quality of life over 24 months, and overall and recurrence-free survival.


Eligibility

Sex: MALEMin Age: 60 Years

Plain Language Summary

Simplified for easier understanding

This study is testing an approach called adaptive stereotactic radiotherapy for men with low- or intermediate-risk prostate cancer. "Adaptive" means the radiation plan is adjusted during treatment to account for how the prostate moves or changes shape, which may reduce side effects and improve accuracy. **You may be eligible if...** - You are a male, 60 years or older - You have low or intermediate risk localized prostate cancer (confined to the prostate, stage T1–T2) - Your Gleason score is 6 or 7 and your PSA is less than 15 ng/mL - Radiotherapy has been recommended as your treatment - You are based in France and can communicate in French **You may NOT be eligible if...** - You cannot read, write, or understand French - You are already participating in another clinical trial that could affect results - You have had previous prostate surgery or bowel surgery that could affect outcomes - You are unable to give independent informed consent Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERLow-dose CT imaging before each SBRT session

Five low-dose, non-contrast CT scans performed immediately before each SBRT session (≈10 min before treatment) to assess anatomical variations impacting target volume and organ-at-risk dosimetry.


Locations(1)

Clinique Sainte Clotilde

Saint-Denis, Reunion

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NCT07344844


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