Augmentation of Peri-implant Keratinized Mucosa Using a Combination of Free Gingival Graft Strip With Platelet-Rich Fibrin
Clinical Effectiveness of Combining Free Gingival Strip Graft With Platelet-Rich Fibrin for Peri-Implant Keratinized Mucosa Augmentation
Nguyen Van Khuong
22 participants
Dec 24, 2025
INTERVENTIONAL
Conditions
Summary
This clinical trial aims to evaluate the clinical effectiveness of combining a strip free gingival graft (sFGG) with Platelet-Rich Fibrin (PRF) for increasing keratinized mucosa around dental implants. The study compares this combined technique with the conventional free gingival graft (FGG) method through three primary objectives: 1. comparing the increase in keratinized mucosal height at immediate post-op, 1, 4, and 6 months; 2. assessing post-operative pain levels at 1, 3, 7, and 14 days; 3. evaluating soft tissue aesthetic outcomes at 4 and 6 months post-surgery.
Eligibility
Inclusion Criteria5
- Patients meeting the following criteria are eligible for the study:
- Prosthetic Phase: Patients scheduled for the prosthetic phase of dental implant treatment.
- Keratinized Mucosa: Keratinized mucosa height (buccal or lingual) of less than 2 mm around the implant.
- Systemic Health: Systemic health status classified as ASA I or II according to the American Society of Anesthesiologists classification.
- Oral Hygiene: Good oral hygiene, defined by a mean full-mouth plaque index (PlI) of ≤ 1.
Exclusion Criteria7
- Patients meeting any of the following criteria will be excluded from the study:
- Systemic Conditions: Presence of systemic diseases or use of medications known to affect the oral mucosa or gingival health.
- Periodontal Health: Untreated periodontal disease and/or peri-implant diseases.
- Surgical History: History of mucogingival surgery at the intended surgical site.
- Pregnancy/Lactation: Pregnant or breastfeeding women.
- Oral Hygiene: Poor oral hygiene, defined by a mean full-mouth plaque index (PlI) \> 1.
- Smoking: Current smokers.
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Interventions
Venous blood is collected using a butterfly needle and 10ml tubes to prepare the PRF membrane. A keratinized mucosa strip of appropriate dimensions is harvested from the patient's palate. The strip free gingival graft and PRF membrane are then sutured and stabilized at the recipient site.
A surgical procedure where a graft consisting of epithelium and connective tissue is harvested from the palate and transplanted to the peri-implant area to increase the width and height of keratinized
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT07346391