Investigation Into the Dynamic Variations of End-Tidal Carbon Monoxide Concentration (ETCOc) in Neonates Utilizing Non-Dispersive Infrared Spectroscopy and Its Implications for Jaundice Management
Investigation Into the Dynamic Variations of End-Tidal Carbon Monoxide Concentration (ETCOc) in Neonates Utilizing Non-Dispersive Infrared Spectroscopy and Its Implications for Jaundice Management.
The Fourth Affiliated Hospital of Zhejiang University School of Medicine
100 participants
Dec 5, 2025
INTERVENTIONAL
Conditions
Summary
The objective of this study is to ascertain the diagnostic threshold of end-tidal carbon monoxide (ETCOc, adjusted for ambient CO levels) within the first three days postpartum, stratified by neonatal age at birth. Additionally, the study aims to evaluate the concordance of the risk range of ETCOc, as measured by non-dispersive infrared spectroscopy, with existing literature, and to assess the reliability of this technology in the management of neonatal hyperbilirubinemia.
Eligibility
Inclusion Criteria2
- Newborns with gestational age of ≥ 37 weeks and birth weight of ≥ 2.5 kg;
- Newborns delivered by either vaginal delivery or cesarean section and with hospital stay of ≥ 3 days.
Exclusion Criteria2
- History of second-hand smoke exposure within 24 hours
- Parents smoke or are exposed to second-hand smoke.
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Interventions
The non-dispersive infrared spectroscopy technique was employed to measure the end-tidal carbon monoxide (ETCOc) levels in newborns at intervals of 12, 24, 48, and 72 hours post-birth.
Locations(1)
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NCT07346976