RecruitingNot ApplicableNCT07348510

Diuretic Effect of Aminophylline and Furosemide in Adult Patients Undergoing Cardiac Surgical Procedures

Comparison Between the Diuretic Effect of Aminophylline and Furosemide in Adult Patients Undergoing Cardiac Surgical Procedures: A Randomized Controlled Trial

Sponsor

Cairo University

Enrollment

106 participants

Start Date

Jan 17, 2026

Study Type

INTERVENTIONAL

Conditions

Cardiac Surgical Procedures Diuretic Effect Aminophylline Furosemide

Summary

This work aims to investigate the diuretic effect of Aminophylline in comparison to Furosemide in adult patients undergoing cardiac surgical procedures.

Eligibility

Min Age: 18 YearsMax Age: 65 Years

Inclusion Criteria4

Age from 18-65 years.
Both sexes.
All adult patients presenting for elective cardiac surgical procedures performed on cardiopulmonary bypass (Coronary artery bypass surgery, Cardiac valve repair and/or replacement, Repair of large septal defects, Repair and/or palliation of congenital heart defects, Transplantation, surgery of thoracic aneurysms.).
Body mass index (BMI) ranged between 20 and 40 kg/m2.

Exclusion Criteria7

Sensitivity or contraindication to Aminophylline or furosemide
Stage-5 chronic kidney disease (CKD) \[Glomerular filtration rate (GFR) of less than 15 mL/min\].
The presence of both factors (GFR less than 60 mL/min and albumin greater than 30 mg per gram of creatinine) along with abnormalities of kidney structure or function for greater than three months signifies chronic kidney disease.
Recipients of dialysis before surgery.
Recipients of solid-organ transplantation before surgery.
Emergency cardiac surgical procedures (e.g. left main coronary artery bypass graft, stuck valves, etc).
Patient refusal.

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