Combination of Nerve Blocks and Local Infiltration Analgesia in Knee Arthroplasty
Postoperative Analgesia in Patients Undergoing Knee Replacement Surgery - a Study Comparing Intraoperative Local Infiltration Analgesia Only With Ultrasound-guided Nerve Blocks Added to Intraoperative Local Infiltration Analgesia, a Randomized Clinical Trial
Region Skane
200 participants
Mar 5, 2026
INTERVENTIONAL
Conditions
Summary
The aim of this clinical randomized trial is to compare local infiltration analgesia (LIA) alone versus the combination of LIA with saphenous nerve (SN) block, block of the nerve to vastus medialis (NVM), and anterior femoral cutaneous nerve (AFCN) block in participants undergoing total knee arthroplasty (TKA). The primary outcome is pain intensity, measured using the Numerical Rating Scale (NRS) at multiple time points after surgery. Secondary outcomes include opioid consumption, time to mobilization, postoperative nausea and vomiting, length of hospital stay, neurological complications and differences in opioid consumption and NRS pain scores between general and spinal anesthesia.
Eligibility
Inclusion Criteria1
- Undergoing primary unilateral total knee arthroplasty
Exclusion Criteria5
- Pregnancy
- Coagulopathy or other bleeding disorder that precludes regional anesthesia
- Allergy to local anesthetics
- Inability to understand spoken and written Swedish
- Unwillingness to participate in the study
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Interventions
Drug used in the block
Locations(1)
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NCT07350252