RecruitingNCT07351786

Impact of the New Generation Anti-diabetic Drugs on Diabetic Retinopathy


Sponsor

Sara A Belal

Enrollment

70 participants

Start Date

Aug 1, 2025

Study Type

OBSERVATIONAL

Conditions

Summary

This study aims to test the impact of new-generation anti-diabetic drugs, such as SGLT2 inhibitors and DPP-4 inhibitors, on the development of diabetic retinopathy (DR). The study hypothesizes that these drugs have protective effects in diabetic retinopathy by delaying its incidence compared to older agents (including metformin) only. Early intervention is critical, as treatment options for advanced stages of DR are limited in terms of their ability to restore impaired vision and their high associated costs. By focusing on delaying the occurrence of diabetic retinopathy, the investigators aim to reduce the burden of DR and improve the quality of life for diabetic patients.


Eligibility

Min Age: 25 Years

Plain Language Summary

Simplified for easier understanding

This study is looking at whether newer diabetes medications — specifically SGLT2 inhibitors and DPP-4 inhibitors — have an effect on diabetic retinopathy, an eye condition caused by diabetes that can damage vision. Researchers want to understand if these drugs help protect eyesight or change how the condition progresses. **You may be eligible if:** - You have been diagnosed with type 2 diabetes for more than 5 years - You have been taking diabetes medications (such as metformin, sulfonylureas, SGLT2 inhibitors, or DPP-4 inhibitors) for 2 to 3 years **You may NOT be eligible if:** - You have gestational diabetes or type 1 diabetes - You already have severe or advanced diabetic eye disease (severe non-proliferative or proliferative diabetic retinopathy) - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Locations(1)

Alexandria University Main Hospitals - Diabetes clinics/ Ophthalmology clinics

Alexandria, Egypt

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NCT07351786


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