RecruitingNot ApplicableNCT07354399

Resistance Training Added to Aerobic Interval Training to Improve Aerobic Capacity and Muscle Mass in Women With Coronary Artery Disease

Resistance Training Among Women With Coronary Artery Disease


Sponsor

University Medical Centre Ljubljana

Enrollment

50 participants

Start Date

Sep 26, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this clinical trial is to find out whether partly replacing aerobic interval training (AIT) with resistance training (RT) leads to greater improvements in physical fitness and muscle mass in women with coronary artery disease (CAD) during cardiac rehabilitation. The main questions this study aims to answer are: * Does combining RT (squats and pulling exercises with weights) with a reduced amount of AIT (cycling) improve aerobic fitness in the same way as AIT alone? * Does the combined training lead to greater improvements in muscle mass compared with AIT alone? * Does slow-speed RT (slower lowering phase) result in lower heart rate and blood pressure during exercise compared with normal-speed RT? Researchers will compare three exercise programs: * AIT only (control group), * AIT combined with normal-speed RT (1-second lifting, 2-second lowering), * AIT combined with slow-speed RT (1-second lifting, 5-second lowering). Participants will take part in a 12-week cardiac rehabilitation program and will train three times per week. At the start and end of the program, participants will complete a cycling fitness test, body composition assessment, blood sampling, two strength tests, and quality-of-life questionnaire.


Eligibility

Sex: FEMALEMin Age: 18 Years

Inclusion Criteria2

  • documented CAD,
  • stable clinical status (at least 1 month since myocardial infarction and/or elective percutaneous coronary intervention, at least 3 months since cardiac surgery).

Exclusion Criteria2

  • based on the American Heart Association guidelines for resistance training in patients with CAD,
  • pregnancy.

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Interventions

OTHERAerobic Interval Training

Interval cycling, performed at 70-80% of the heart rate reserve (HRR) as determined during the cardiopulmonary exercise test. The training is structured as alternating high- and low-intensity intervals.

OTHERTraditional Resistance Training

Resistance training with traditional tempo (1-second ascent, 2-second descent) - squat exercise and horizontal pull.

OTHERProlonged Eccentric Phase Resistance Training

Resistance training with prolonged eccentric phase tempo (1-second ascent, 5-second descent) - squat exercise and horizontal pull.


Locations(1)

University Medical Centre Ljubljana (Department of Vascular Diseases, Division of Internal Medicine)

Ljubljana, Slovenia

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NCT07354399


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