RecruitingNCT07357181

Influence of Handedness on Upper Limb Recovery

Impact of Manual Preference on Motor Deficits After Stroke

Sponsor

Centre Hospitalier Régional d'Orléans

Enrollment

500 participants

Start Date

Jun 2, 2026

Study Type

OBSERVATIONAL

Conditions

Stroke

Summary

This prospective, single-center observational study evaluates whether handedness is associated with upper-limb motor recovery after a recent unilateral stroke. Adults admitted to the stroke unit with a confirmed unilateral stroke within 5 days are included if they do not object to participation. Upper-limb impairment is assessed early after stroke and at 6 months using standardized clinical scales. Handedness is determined by self-report, and the Edinburgh Handedness Inventory is administered when feasible. The main hypothesis is that left-handed participants may show better upper-limb motor recovery at 6 months than right-handed participants, potentially due to differences in brain motor network lateralization.

Eligibility

Min Age: 18 Years

Inclusion Criteria3

Confirmed unilateral recent stroke (less than 5 days).
Age 18 years and older.
Participant or proxy does not object to participation

Exclusion Criteria5

Prior stroke with residual motor sequelae.
Pre-stroke upper-limb deficit.
Follow-up at 6 months not planned at Orléans.
Protected adult (guardianship/curatorship), person under legal protection, or deprived of liberty.
Pregnant or breastfeeding woman.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

OTHERevaluation

Patients will be evaluated at baseline for Edinburgh Handedness Inventory Laterality Quotient. Patients will be seen again at 6 months as part of their standard post-stroke consultation at Orléans University Hospital by a neurologist from the neurology department. In conjunction with this consultation, an assessment specific to this research study of the FMA-UE and SAFE scores will be carried out by a physiotherapist from the department.