OCTA in Cardiovascular Disease and Healthy Controls
Optical Coherence Tomography Angiography (OCTA) for the Assessment of Retinal Capillary Density in Patients With Cardiovascular Disease and a Healthy Control Group
University of Erlangen-Nürnberg Medical School
64 participants
Dec 1, 2025
INTERVENTIONAL
Conditions
Summary
This prospective clinical study will involve the non-invasive assessment of retinal vessels using OCTA (Cirrus OCT 6000 AngioPlex) and scanning laser Doppler flowmetry (SLDF) in patients with cardiovascular disease and healthy individuals. The study will be conducted at the Clinical Research Centre (CRC), Department of Nephrology and Hypertension at the University of Erlangen-Nuremberg.
Eligibility
Inclusion Criteria4
- cardiovascular disease defined as one or more of the following: arterial hypertension, type 2 diabetes mellitus, chronic kidney disease, heart failure
- BMI 18-29.9 kg/m2
- Non-smoker
- Good general health, as determined by study personnel based on assessments of previous visits, including anamnesis, vital signs, physical examination and clinical laboratory parameters.
Exclusion Criteria9
- Active ophthalmological (retinal) disease resulting in impaired visual assessment of retinal vessels (e.g. glaucoma, cataracts, retinal oedema).
- Active ophthalmological (retinal) disease with reduced visual assessment of retinal vessels (e.g. glaucoma, cataracts, retinal oedema).
- clinically relevant deviation in physical examination, vital signs, or laboratory parameters (based on the physician's clinical judgement).
- a clinically relevant history of cardiovascular disease or any other previously known cardiovascular disease
- History of clinically relevant neurological, gastrointestinal, renal, hepatic, psychological, pulmonary, metabolic, endocrine or other diseases
- office blood pressure above or equal to 140/90 mmHg
- Office heart rate outside of the following range: 50-99 bpm
- regular intake of any medication for the treatment of cardiovascular diseases (e.g. antihypertensive or antidiabetic medication) within one month before study inclusion
- alcohol or drug abuse
Interventions
Assessment of retinal capillary density using OCTA and SLDF
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT07359664