RecruitingNot ApplicableNCT07359911

Effect of A Multimodal Exercise Intervention on Chemotherapy Uptake in Newly Diagnosed Pediatric and AYA Sarcoma Patients

Effect of A Multimodal Exercise Intervention on Chemotherapy Uptake in Newly Diagnosed Pediatric and AYA Sarcoma Patients (ACTIVE-SARC)


Sponsor

University of Miami

Enrollment

40 participants

Start Date

Feb 5, 2026

Study Type

INTERVENTIONAL

Conditions

Summary

The purpose of this study is to determine the effects of a multimodal exercise intervention on chemotherapy uptake in newly diagnosed pediatric, adolescent and young adult (AYA) Sarcoma patients.


Eligibility

Min Age: 12 YearsMax Age: 39 Years

Plain Language Summary

Simplified for easier understanding

This study investigates whether a structured exercise program during chemotherapy helps young cancer patients (teens and young adults with sarcoma) complete more of their planned chemo doses, and improves their physical fitness and quality of life. **You may be eligible if...** - You are between 12 and 39 years old - You have been diagnosed with sarcoma (a cancer of bones or soft tissues) - You are starting or have recently started (within the past 90 days) your first round of chemotherapy - You can read and understand English or Spanish - You have not been regularly exercising (less than 90 minutes of moderate exercise per week) - Your cancer care team approves your participation **You may NOT be eligible if...** - You require supplemental oxygen - You cannot walk two city blocks without assistance (other than a cane) - You have unstable bone metastases (cancer spread to bones in a way that makes exercise risky) - You started chemotherapy more than 90 days ago - You have a severe medical or psychiatric condition that prevents participation Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALExercise Intervention

Each session will include a brief conversation and standardized symptom assessment, followed by a warm-up including stretching \& balance exercises, then a series of resistance exercises, ending with light-moderate intensity aerobic exercise (walking), with a target goal of 45-60 minutes total per session as tolerated by the patient.

BEHAVIORALUsual Care Control

A weekly brief symptom self-assessment as a survey will be delivered by Redcap survey, in person or remotely, or by telephone with researcher assistance. Completion of the survey will take approximately 10 minutes per week.

BEHAVIORALExit Interview

A semi-structured interview will be administered at 12 weeks to the intervention (EXE) group only to explore self-determination and efficacy, as well as intervention acceptability.


Locations(1)

University of Miami

Miami, Florida, United States

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NCT07359911


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