A Phase Ib/III Study of Suvemcitug Plus FTD/TPI in Participants With Refractory Metastatic Colorectal Cancer

This study tests whether adding a drug called suvemcitug to a standard chemotherapy pill (FTD/TPI, also called trifluridine/tipiracil) works better than current treatments for people with advanced colorectal cancer (bowel cancer that has spread) that has stopped responding to prior therapies. **You may be eligible if...** - You have advanced or metastatic colorectal cancer confirmed by biopsy - Your cancer has at least one measurable tumor - You have already been treated with standard chemotherapy regimens including fluorouracil, oxaliplatin, and irinotecan, and anti-VEGF therapy (and anti-EGFR therapy if your tumor has normal RAS) - Your cancer has progressed or you could not tolerate your last treatment - Your organ and bone marrow function is adequate **You may NOT be eligible if...** - You have another active cancer within the past 5 years - You have active or symptomatic brain metastases - You have uncontrolled fluid buildup in your chest or abdomen - You have had a serious active infection in the past 2 weeks - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.