RecruitingNot ApplicableNCT07361471

Identification of Genetic, Phenotypic, Clinical, Biological and Histological Factors Differentiating Patients With Ovarian Cancer Who Are Refractory to Platinum-based Therapy From Patients Defined as Long-term Responders to Platinum-based Therapy

Identification of Genetic, Phenotypic, Clinical, Biological and Histological Factors Differentiating Patients With Ovarian Cancer Who Are Refractory to Platinum-based Therapy From Patients Defined as Long-term Responders to Platinum-based Therapy.


Sponsor

Centre Jean Perrin

Enrollment

55 participants

Start Date

Jan 22, 2026

Study Type

INTERVENTIONAL

Conditions

Summary

After having constituted the ORTRAI cohort using the CONSORE database at the Jean PERRIN Center, the objective is to characterize the patients both clinically and biologically, histologically and genomically. The clinical and biological characterizations will allow us to confirm that our cohort is comparable with data from the literature. The complement of immunohistochemical and molecular analyses will provide more details on the differences between long-term patients responding to treatment and refractory patients.


Eligibility

Sex: FEMALEMin Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study collects and analyzes genetic, biological, and clinical data from women with ovarian cancer to understand why some patients respond extremely well to standard platinum-based chemotherapy (long-term survivors) while others do not respond at all (refractory patients). **You may be eligible if...** - You are an adult woman treated at the Jean Perrin Center - You have ovarian cancer at any stage that was treated with platinum-based chemotherapy as first-line treatment - You fall into one of two categories: your cancer progressed during first-line chemo (refractory), OR you have had no recurrence for at least 5 years after completing first-line chemo (long-term responder) - You have signed a genetic consent form **You may NOT be eligible if...** - You are a minor - You are pregnant - You are under legal guardianship - You object to the use of your medical data - The hospital does not have your tumor tissue sample available for genetic analysis Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

GENETICmolecular analysis

molecular analysis on histological blocks


Locations(1)

Centre Jean Perrin

Clermont-Ferrand, PUY DE DOME, France

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NCT07361471


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