RecruitingNot ApplicableNCT07362550

Effects of 12-Week Balanced Diet on Body Composition & Metabolic Parameters in Twins

A Comparative Study of Monozygotic and Dizygotic Twins: Evaluating the Effects of a 12-Week Balanced Diet Intervention on Body Composition and Metabolic Parameters.

Sponsor

University of Veterinary and Animal Sciences, Lahore - Pakistan

Enrollment

60 participants

Start Date

Jan 17, 2026

Study Type

INTERVENTIONAL

Conditions

Healthy Adults

Summary

Twin study in Lahore will assess genetic vs. environmental effects on diet and metabolism. Over 12 weeks, monozygotic and dizygotic twins will follow a WHO-aligned balanced diet. Body composition, metabolic markers, and adherence will be measured. Monozygotic twins are expected to show greater similarity in response, clarifying personalized nutrition strategies in Pakistan.

Eligibility

Min Age: 18 YearsMax Age: 60 Years

Inclusion Criteria5

Male or female twins aged 18-60 years.
Confirmed zygosity (MZ or DZ) based on a validated twin zygosity questionnaire.
Both twins willing to participate for the entire intervention period.
Free from chronic diseases requiring specialized diets (e.g., type 1 diabetes, celiac disease).
Not currently enrolled in another dietary or lifestyle intervention study.

Exclusion Criteria4

Pregnant or lactating women.
Use of lipid-lowering, glucose-lowering, or weight-loss medications in the past 3 months.
Major gastrointestinal disorders or conditions affecting nutrient absorption.
Unwillingness to follow individualized dietary counseling or complete study assessments.

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Interventions

OTHERBalanced Diet

12-week culturally adapted WHO-aligned balanced diet emphasizing whole grains, lean proteins, healthy fats, fruits, and vegetables. Macronutrient composition: 45-65% carbohydrates, 20-35% fats, 10-20% protein. Individualized based on basal metabolic rate (BMR) and physical activity. Weekly counseling and monitoring through dietary recalls and photographic diaries. This intervention aims to assess the effects of a balanced diet on body composition and metabolic parameters in monozygotic and dizygotic twins.