RecruitingNot ApplicableNCT07363343

Nifedipine and Enalapril vs Nifedipine and Labetalol for the Treatment of Postpartum Hypertension Study

Nifedipine and Enalapril vs Nifedipine and Labetalol for the Treatment of Postpartum Hypertension Study (NEPHRON)

Sponsor

The Cleveland Clinic

Enrollment

200 participants

Start Date

Mar 10, 2026

Study Type

INTERVENTIONAL

Conditions

To determine if nifedipine and enalapril will have better blood pressure control in the postpartum setting compared to nifedipine and labetalol.

Sex: FEMALEMin Age: 18 Years

Postpartum women aged 18 years or older
Clinical diagnosis of hypertensive disorder in pregnancy (gestational hypertension, chronic hypertension, preeclampsia with or without severe features)
Taking Nifedipine 60 mg every 12 hours for blood pressure control
Persistently elevated blood pressure at/above 140/90 mmHg in a 24-hour time period or have one or more severe range blood pressure at/above 160/110 mmHg requiring a second antihypertensive medication
English speaking

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DRUGNifedipine and Enalapril

Nifedipine 60mg by mouth every twelve hours plus Enalapril 5mg by mouth every twelve hours

DRUGNifedipine and Labetalol

Nifedipine 60mg by mouth every twelve hours plus Labetalol 200mg by mouth every twelve hours

Cleveland Clinic

Cleveland, Ohio, United States

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NCT07363343