Multicenter Randomized Controlled Trial (RCT) and Efficacy Evaluation System Study on Surgical Innovation Strategies for Neonatal Complex Congenital Heart Disease
Central China Fuwai Hospital of Zhengzhou University
738 participants
Dec 1, 2025
INTERVENTIONAL
Conditions
Summary
There remains controversy regarding the optimal timing of surgical treatment for neonatal CCHD (Complex Congenital Heart Disease). Based on the established national multi-center database for surgical treatment of congenital heart disease and the prenatal-postnatal integrated diagnosis and treatment model, this study will conduct a multi-center RCT (Randomized Controlled Trial) to explore the optimal surgical timing for neonatal CCHD. It will also develop innovative comprehensive treatment strategies for critically ill neonatal CCHD patients, use RCT data to evaluate treatment efficacy and establish an evaluation system. This system will be gradually promoted nationwide, aiming to reduce the incidence of perioperative mortality and non-recovery discharge in CCHD patients by 50% (National in-hospital mortality rate of neonatal congenital heart disease surgery in 2023: 6.5%; non-recovery discharge rate: 12.66%), thereby improving the overall level of CCHD treatment in China.
Eligibility
Inclusion Criteria2
- Neonates diagnosed with TAPVC, CoA/IAA, TGA, PA/IVS, or severe PS via pre-admission cardiac echocardiography;
- Patients and families demonstrating high compliance, willing to sign informed consent forms and agree to complete one year of follow-up and related examinations.
Exclusion Criteria4
- Preterm infant (gestational age < 36 weeks at birth);
- Low birth weight (weight < 2.5 kg);
- Concurrent severe extracardiac anomalies or complex cardiac malformations;
- Preoperative respiratory or circulatory instability requiring emergency surgery.
Interested in this trial?
Get notified about updates and connect with the research team.
Interventions
Surgical operation is performed on neonates aged \>7 days (postnatal age)
Surgical operation is performed on neonates aged \< 7 days (postnatal age).
Locations(12)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT07363538