RecruitingNot ApplicableNCT07365566

Pain Assessment in Patients With Idiopathic Rapid Eye Movement (REM) Sleep Behaviour Disorder

Pain Assessment in Patients With Idiopathic REM Sleep Behaviour Disorder

Sponsor

University Hospital, Toulouse

Enrollment

24 participants

Start Date

Feb 24, 2026

Study Type

INTERVENTIONAL

Conditions

REM Sleep Behavior Disorder (iRBD)Narcolepsy Type 1

Summary

Parkinson's disease (PD) is the second most common neurodegenerative disorder after Alzheimer's disease, with over 12 million patients expected globally by 2040. The disease is currently diagnosed at the appearance of motor symptoms, but by then, over 60% of striatal dopaminergic neurons have already been destroyed. Prodromal symptoms such as idiopathic REM Sleep Behavior Disorder (iRBD), anosmia, mood disorders and constipation appear earlier and are listed as criteria for a prodromal PD diagnosis. Identifying early signs is critical to initiate neuroprotective treatments as early as possible. While pain is prevalent and highly disabling in early PD, no data are currently available on pain perception in iRBD patients, whose condition is of the main risk factor for PD development.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is measuring how people with a sleep disorder called idiopathic REM Sleep Behaviour Disorder (iRBD) — where people physically act out their dreams — experience and respond to pain, as this condition is a strong early warning sign for Parkinson's disease. **You may be eligible if...** - You have been diagnosed with iRBD confirmed by a sleep study (polysomnography), and you have NOT been diagnosed with Parkinson's disease or another neurodegenerative disease, OR - You have narcolepsy type 1 with confirmed REM sleep behaviour disorder (as a comparison group) - You are able to understand and complete questionnaires and study procedures **You may NOT be eligible if...** - You have already been diagnosed with Parkinson's disease, Lewy body dementia, or multiple system atrophy - You have severe depression - You are unable to complete the required questionnaires or assessments Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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