Clinical Characteristics, Frailty, and Prognostic Predictors in Patients Aged 75 and Older With Acute Coronary Syndrome
Investigation of Clinical Characteristics, Frailty, and Predictors of In-Hospital and Six-Month Prognosis in Hospitalized Patients Aged 75 Years and Older With Acute Coronary Syndrome
Clinical Center Niš
550 participants
May 13, 2026
OBSERVATIONAL
Conditions
Summary
This study will evaluate clinical characteristics, frailty, and predictors of prognosis in patients aged 75 years and older who are hospitalized with acute coronary syndrome (ACS). The research includes both a retrospective and a prospective cohort. The aim is to determine whether frailty scores, combined with clinical and laboratory parameters available at admission, can improve risk prediction for complications and mortality compared with standard risk scores (TIMI, GRACE, Syntax). The study will also compare outcomes between patients treated with percutaneous coronary intervention (PCI) and those treated conservatively with medications. Patients will be followed during hospitalization and for six months after discharge. The results are expected to contribute to more personalized treatment strategies for elderly patients with ACS.
Eligibility
Inclusion Criteria4
- Age ≥ 75 years
- Diagnosis of acute coronary syndrome (STEMI, NSTEMI, or unstable angina)
- Hospitalization in a tertiary care center (University Clinical Center Niš)
- For prospective cohort: signed informed consent
Exclusion Criteria2
- Refusal to provide informed consent (prospective cohort)
- Missing or incomplete medical documentation (retrospective cohort)
Interested in this trial?
Get notified about updates and connect with the research team.
Interventions
Patients receiving PCI as part of routine clinical care
Patients treated conservatively with guideline-directed medical therapy as part of routine care
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT07366684