RecruitingNCT07372664

External Validation of VVI

External Validation of the Volume-Velocity Index for Weaning Prediction: a Multicenter Observational Study


Sponsor

University of Thessaly

Enrollment

100 participants

Start Date

Dec 28, 2025

Study Type

OBSERVATIONAL

Conditions

Summary

Failure of liberation from mechanical ventilation increases days spent being mechanically ventilated, the length of stay and the morbidity of patients. Thus it is crucial that those patients who are ready to be liberated are accurately detected. In this study the investigators want to externally validate an index (the volume-velocity index, VVI) which in a preliminary study was found to predict with high accuracy the outcome of ventilator liberation. In this study, in patients who are deemed ready to undergo weaning by their treating physician the investigators will measure the excursion of the diaphragm, the principal respiratory muscle, the inspiratory time and the tidal volume and the volume breathed by the patient at each respiration in three phases: 1. during pressure support ventilation with 5/5, 2. during pressure support ventilation with 8/0, 3. during t-tube or pressure support ventilation with 0/0. All of these phases are ventilatory modalities widely used during weaning from mechanical ventilation. The investigators will evaluate whether VVI can predict accurately the weaning outcome.


Eligibility

Min Age: 18 Years

Inclusion Criteria3

  • Mechanically ventilated patients for more than 48h
  • First Spontaneous breathing trial
  • Deemed as ready to undergo weaning by the treating physician, according to published readiness criteria (DOI: 10.1183/09031936.00010206)

Exclusion Criteria3

  • pregnant patients
  • preexisting diaphragmatic disease or injury
  • tracheostomy

Interested in this trial?

Get notified about updates and connect with the research team.


Locations(3)

General University Hospital of Larissa

Larissa, Greece

AHEPA - University General Hospital

Thessaloniki, Greece

General Hospital of Thessaloniki "G. Papanikolaou"

Thessaloniki, Greece

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT07372664


Related Trials