HOXB7 and Linked Tissue and Blood Biomarkers in the Lungs of Patients With Pulmonary Fibrosis
University of Modena and Reggio Emilia
80 participants
Jul 1, 2023
OBSERVATIONAL
Conditions
Summary
This pilot, multicenter, interventional study investigates the expression of HOXB7 and its associated molecular pathway in lung tissue and blood-derived exosomes from patients with pulmonary fibrosis (PF), including idiopathic pulmonary fibrosis (IPF). Using RNA sequencing (RNA-Seq) and proteomic analysis via mass spectrometry (MS), the study aims to identify tissue and circulating biomarkers associated with fibrosis progression. The study compares different biopsy techniques (surgical vs. transbronchial cryobiopsy) and also includes a control group of patients undergoing lung resection for non-fibrotic conditions.
Eligibility
Inclusion Criteria3
- Adults aged 18 to 80 with clinical suspicion of pulmonary fibrosis
- Availability of fresh lung tissue from biopsy or lung explant
- Signed informed consent for research use of biological material and data
Exclusion Criteria1
- \- Refusal to sign informed consent
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Interventions
This is a non-therapeutic, observational sampling study. Procedures include: Lung tissue sampling via: Surgical biopsy Transbronchial cryobiopsy Explanted lungs from transplant patients Blood sampling for exosome analysis
Locations(1)
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NCT07373288