RecruitingPhase 2Phase 3NCT07373782

Continuous Positive Airway Pressure (CPAP) Assisted Radiotherapy in Breast Cancer

Reducing Cardiac Radiation Dose in Continuous Positive Airway Pressure (CPAP) Assisted Radiotherapy in Breast Cancer: a Prospective Non-Randomized Clinical Trial


Sponsor

Universitaire Ziekenhuizen KU Leuven

Enrollment

53 participants

Start Date

Feb 11, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

This study is a prospective, non-randomized clinical study aimed at investigating the potential benefits of continuous positive airway pressure (CPAP) support during radiotherapy for breast cancer. CPAP is a device commonly used to support breathing, for example in patients with sleep apnea. The investigators expect a reduction in radiation doses to the heart and/or lungs with CPAP-supported radiotherapy compared to standard radiotherapy (without CPAP), which may also lead to a decrease in radiation-induced heart and/or lung conditions in the long term. The study will also examine how the use of a CPAP device can be implemented in daily radiotherapy practice.


Eligibility

Sex: FEMALEMin Age: 40 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether using CPAP (a continuous positive airway pressure device, similar to sleep apnea therapy) during radiation treatment for breast cancer can help protect the heart from radiation exposure by shifting the chest position. **You may be eligible if...** - You are a woman between 40 and 80 years old - You have had breast-conserving surgery (lumpectomy) for breast cancer - You have been recommended to receive radiation therapy to the breast or lymph nodes - Prior chemotherapy, immunotherapy, or hormonal therapy is allowed **You may NOT be eligible if...** - You have certain lung conditions such as bullous lung disease or a collapsed lung that are contraindications to CPAP - You have had major head trauma or a CSF leak (also contraindications to CPAP use) - You are pregnant or planning to become pregnant - You are a male breast cancer patient - You have had a full mastectomy rather than breast-conserving surgery Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

DEVICEContinuous Positive Airway Pressure (CPAP)

Positive airway pressure (15cmH2O) delivered by a CPAP-device


Locations(1)

UZ Leuven

Leuven, Belgium

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT07373782


Related Trials