RecruitingNot ApplicableNCT07378319

Dextrose Hydrodissection for Post-Breast Cancer Chest Wall and Axillary Tightness.

Effectiveness of Ultrasound-Guided Dextrose Prolotherapy for Persistent Chest Wall and Axillary Symptoms in Breast Cancer Survivors: A Prospective Case Series.


Sponsor

Taichung Veterans General Hospital

Enrollment

15 participants

Start Date

Jan 11, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this clinical trial (prospective case series) is to evaluate the feasibility, safety, and preliminary clinical outcomes of ultrasound-guided dextrose prolotherapy in female breast cancer survivors with persistent ipsilateral chest wall and axillary pain and tightness who have plateaued with standard physical therapy. The main questions it aims to answer are: Does ultrasound-guided dextrose prolotherapy significantly improve upper extremity functional limitation (measured by the QuickDASH questionnaire)? What are the effects of this intervention on pain intensity (NRS), active shoulder range of motion (AROM), and anterior chest wall soft-tissue tightness (pectoralis minor muscle length)? Participants will: Undergo a comprehensive baseline physical examination and ultrasound assessment of the symptomatic chest wall and axilla. Receive three sessions of ultrasound-guided 5% dextrose injections into targeted soft-tissue planes at 4-week intervals. Continue their designated standard rehabilitation program, including range-of-motion and stretching exercises. Attend follow-up assessments at 4-week intervals during the treatment phase, with long-term follow-up at 3 and 6 months after the final injection to evaluate the durability of the response.


Eligibility

Sex: FEMALEMin Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study tests dextrose prolotherapy — injections of concentrated sugar water into connective tissue — as a treatment for persistent chest wall and underarm tightness or pain that continues more than 3 months after breast cancer surgery and has not improved with standard physical therapy. **You may be eligible if...** - You have had breast cancer surgery (mastectomy or lumpectomy), with or without lymph node removal - You still have significant chest or underarm pain, tightness, or movement restriction at least 3 months after surgery - Your symptoms haven't significantly improved after 12 weeks of standard physical therapy - You are 18 or older **You may NOT be eligible if...** - Your breast cancer has come back or spread - You currently have active lymphedema requiring treatment - You have a bleeding disorder or are on blood thinners that would make injections unsafe - You have an active infection or unhealed wound at the injection site - You are allergic to dextrose - You are pregnant Talk to your doctor to see if this trial is right for you.

This is a simplified summary. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDUREultrasound guided dextrose prolotherapy

Participants receive three sessions of ultrasound-guided 5% dextrose injections into symptomatic myofascial and interfascial planes of the ipsilateral chest wall and axillary region. The technique involves identifying areas of soft-tissue thickening or restricted fascial glide under high-frequency ultrasound. Injection targets are individualized to each patient's specific site of restriction (e.g., clavipectoral fascia, pectoralis major-minor interface, or axillary fascia). Sessions are administered at 4-week intervals (at weeks 0, 4, and 8).


Locations(1)

Taichung Veterans Genetal Hospital

Taichung, Taiwan, Taiwan

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NCT07378319


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