A Clinical Study of GK02 in Malignant Ascites

This study evaluates the safety and effectiveness of GK02, an experimental drug, for treating malignant ascites — a buildup of fluid in the abdomen caused by advanced cancer that has not responded to at least two prior treatments. **You may be eligible if...** - You are 18–75 years old with confirmed advanced solid tumors (such as gastric, colorectal, pancreatic, or ovarian cancer) that have not responded to at least two prior treatments - You have been diagnosed with malignant ascites and your doctor believes treatment is needed - Your abdomen fluid level is confirmed to be at least moderate by ultrasound - Your overall health status is adequate (ECOG 0–2) - Your organ function is within acceptable ranges **You may NOT be eligible if...** - You have had a severe allergic reaction to a similar drug - You have received recent treatment for the ascites in the past 14 days - You are pregnant or breastfeeding - You have conditions that make abdominal puncture unsafe Talk to your doctor to see if this trial is right for you.