ClinicalTrialsFinder
RecruitingNCT07379242

Lung Recruitment Assessed by 2D/3D-EIT and R/I Ratio in Acute Respiratory Failure Patients With Mechanical Ventilation

Lung Recruitment Assessed by Two-Dimensional/Three-Dimensional Electrical Impedance Tomography and Recruitment-to-Inflation Ratio in Acute Respiratory Failure Patients With Mechanical Ventilation

Sponsor

Peking Union Medical College Hospital

Enrollment

50 participants

Start Date

Sep 1, 2025

Study Type

OBSERVATIONAL

Conditions

Acute Respiratory Failure (ARF)

Summary

The purpose of this observational study is to assess the differences and consistency in evaluating lung recruitment potential between the recruitment-to-inflation ratio (R/I ratio) and three-dimensional electrical impedance tomography (3D-EIT) and two-dimensional EIT (2D-EIT) in mechanically ventilated patients with acute respiratory failure. The main questions it aims to answer is: Are the lung recruitment potentials predicted by 3D-EIT, 2D-EIT and the R/I ratio consistent? Participants will: Undergo a standardized PEEP titration protocol with synchronized EIT monitoring; Have R/I ratios measured at high and low PEEP levels.

Eligibility

Min Age: 18 Years

Inclusion Criteria3

  • Mechanically ventilated patients under sedation and analgesia with no spontaneous breathing.
  • Oxygenation index < 300 mmHg.
  • Patients who are clinically judged by the attending doctor to require the PEEP titration.

Exclusion Criteria6

  • Aged under 18 years.
  • Pregnancy.
  • Contraindications for EIT examination (e.g. automatic implantable cardioverter defibrillator, implantable pumps, chest wounds limiting electrode belt placement, severe thoracic deformity, and others).
  • No informed consent obtained.
  • Hemodynamic instability with intolerance to high PEEP levels determined by the attending doctor.
  • High-risk populations with pneumothorax, mediastinal emphysema, and other such conditions determined by the attending doctor.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

DIAGNOSTIC_TESTThe lung recruitment potential assessed and PEEP titration by ventilator and 2D/3D EIT

The patient will undergo a standardized PEEP titration procedure and determination of the Recruitment-to-Inflation ratio (R/I ratio), with concurrent monitoring by both 2D- and 3D- EIT.

Locations(1)

Department of Critical Care Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences

Beijing, Beijing Municipality, China

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT07379242

Related Trials

Bed Side Assessment in Patients With Acute Respiratory Failure Under Invasive Mechanical Ventilation

NCT072658821 location

Music Therapy During NIV Implantation in Pediatric Intensive Care Units

NCT068482181 location