Evaluation of Postoperative Adjuvant Chemotherapy Efficacy for Bladder Cancer Based on Organoid Technology.

Exclusion Criteria15

• \. Severe, life-threatening complications occurring after radical cystectomy, such as cardiovascular complications, renal failure, respiratory failure, liver failure, sepsis, pulmonary embolism, and major hemorrhage; 2. Individuals with immunodeficiency or impairment (e.g., patients with AIDS, or those receiving immunosuppressants or radiotherapy); 3. Participants known to be allergic to the study drug, similar drugs, or excipients, or those with an allergic constitution; 4. Individuals taking long-term corticosteroids or with a history of drug abuse or dependence; 5. Individuals planning pregnancy soon, currently pregnant, or breastfeeding; 6. Abnormal blood routine, liver and kidney function, and coagulation indices (considered abnormal if one or more of the following are met):
• Absolute neutrophil count (ANC) ≤ 1.5 × 10⁹/L;
• White blood cell count (WBC) ≤ 3.0 × 10⁹/L;
• Platelet count (PLT) ≤ 90 × 10⁹/L;
• Hemoglobin (HB) ≤ 90 g/L;
• Total bilirubin (TBIL) ≥ 1.5 × upper limit of normal (ULN) for the institution;
• Estimated glomerular filtration rate (eGFR) ≤ 30 ml/min/1.73m²;
• International normalized ratio (INR) and activated partial thromboplastin time (APTT) ≥ ULN (excluding patients on anticoagulant therapy, if considered clinically acceptable by the investigator); 7. Other factors that may cause the study to be prematurely terminated, such as:
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• Patients with a past or current diagnosis of myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML);
• A history of clear neurological or psychiatric disorders, including epilepsy or dementia;
• Comorbidities that pose a serious risk to patient safety or could affect study completion (e.g., severe hypertension, diabetes, thyroid disorders, etc.);
• Other serious diseases requiring combined treatment or with severe laboratory abnormalities;
• Other serious diseases accompanied by familial or social factors that could affect participant safety, or the collection of data and samples;
• Uncontrolled comorbid conditions, including but not limited to ongoing or active infections requiring treatment, symptomatic congestive heart failure, unstable angina, or arrhythmias; 8. Individuals deemed by the investigator as unsuitable to participate in the study.