Melatonin on Post Operative Pain After CS
The Effect of Preoperative Oral Melatonin on Postoperative Pain Control After Cesarean Section: A Dose Comparison Study
Benha University
60 participants
Oct 10, 2025
INTERVENTIONAL
Conditions
Summary
The goal of this clinical trial is to learn if melatonin will decrease pain after C.S. The main questions it aims to answer are: Does melatonin lower the number of times participants need to use a rescue analgesia? What medical problems do participants have when taking melatonin? Researchers will compare different doses of melatonin to see the ideal dose to decrease pain after C.S. Participants will: Take melatonin 30 min before C.S and will be observed for 24 hours for pain and consumption of other analgesia
Eligibility
Inclusion Criteria3
- \- Women aged 18-40 years.
- Scheduled for elective cesarean section.
- Ability to provide informed consent.
Exclusion Criteria7
- Known hypersensitivity to melatonin or opioids
- Chronic use of analgesics, sedatives, or antidepressants.
- History of sleep disorders or psychiatric illness.
- Complicated pregnancies (e.g., preeclampsia, gestational diabetes).
- Body mass index (BMI) \> 35 kg/m².
- Emergency cesarean sections.
- Severe systemic diseases (e.g., liver or kidney dysfunction).
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Interventions
Group I: (5 mg melatonin): Participants will receive 5 mg of oral melatonin 1 hours before the cesarean section.
Group II: (10 mg melatonin): Participants will receive 10 mg of oral melatonin 1 hours before the cesarean section.
Group III: (Placebo): Participants will receive an identical placebo tablet 1 hours before the cesarean section.
Locations(1)
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NCT07380568