A Clinical Study of Inhaled Nitric Oxide in Patients With Chronic Obstructive Pulmonary Disease

This study is testing inhaled nitric oxide — a gas delivered through the nose — as a treatment for people with moderate-to-severe chronic obstructive pulmonary disease (COPD), a lung condition that makes breathing difficult. Researchers want to see if this approach improves lung function and reduces symptoms. **You may be eligible if...** - You are between 40 and 75 years old - You have a history of smoking (at least 10 pack-years) and have quit for at least one month - You have been diagnosed with moderate-to-severe COPD confirmed by breathing tests - You are able and willing to follow all study procedures **You may NOT be eligible if...** - You are pregnant or breastfeeding - You have used nicotine products (patches, gum, etc.) in the past month - You have asthma or another active lung condition besides COPD - Your nose is physically blocked - You had a COPD flare-up requiring steroids within the past month - You have significant heart problems, including reduced heart pumping function or serious valve disease - You currently take pulmonary hypertension medications (e.g., sildenafil, bosentan) - You are currently in another drug or device clinical trial Talk to your doctor to see if this trial is right for you.