RecruitingNot ApplicableNCT07384013
Study Protocol: Impact of Metamizole (Optalgin®) on Anti-Xa Concentrations in Oncology Patients Receiving DOACs
Impact of Metamizole (Optalgin®) on Anti-Xa Concentrations in Oncology Patients Receiving DOACs
Sponsor
Rambam Health Care Campus
Enrollment
30 participants
Start Date
Nov 1, 2025
Study Type
INTERVENTIONAL
Conditions
Summary
Evaluation of the Effect of metamizole (Optalgin®) on Anti-Xa Levels in Oncology Patients Receiving Direct Oral Anticoagulants (DOACs)
Eligibility
Min Age: 18 Years
Inclusion Criteria6
- Adult oncology patients (≥18 years old).
- Receiving apixaban or rivaroxaban for anticoagulation.
- New/current metamizole users taking at least 1g TID for pain management.
- Platelets ≥100×10⁹/L
- ECOG PS<3
- Provided informed consent
Exclusion Criteria2
- History of allergic reaction to metamizole or DOACs.
- Individuals with significant gastrointestinal disorders that may affect absorption, including (but not limited to) diagnosed bowel obstruction, persistent diarrhea, or the presence of a nasogastric tube (NGT/zonda)
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Interventions
DRUGmetamizole
chronic metamizole use
DRUGmetamizole
New metamizole users
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT07384013
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