Immune Cells Role in Lung Cancer and Their Use in Anticancer Immunotherapies and Inflammatory Lung Disease

This study is investigating the role of immune cells in lung cancer and chronic inflammatory lung diseases like COPD and sarcoidosis. Researchers will collect and analyze immune cells from patients to better understand how these diseases develop and to potentially improve immunotherapy treatments. **You may be eligible if...** - You have been diagnosed with lung cancer or have precancerous lung lesions - You have a chronic inflammatory lung disease (COPD or sarcoidosis) and have not yet started treatment - You are a healthy adult with no known lung disease (for the control group) - You are a child weighing at least 10 kg with a genetic condition called chronic granulomatous disease (CGD) - You are an adult scheduled for orthopedic surgery that involves bone marrow collection **You may NOT be eligible if...** - You take systemic corticosteroids at a dose higher than 10 mg/day of prednisone - You have an active infection at the time of enrollment - You are unable or unwilling to give informed consent - You have a chronic inflammatory lung disease currently being treated with immune-suppressing medications Talk to your doctor to see if this trial is right for you.