Comparing PIEB and CEI for Labor Pain Relief
Comparison of Continuous Epidural Infusion vs. Programmed Intermittent Epidural Bolus Combined With Patient-Controlled Epidural Analgesia for Labor Pain Relief: A Randomized Controlled Trial
Da Nang Family General Hospital
60 participants
Jul 30, 2025
INTERVENTIONAL
Conditions
Summary
The purpose of this randomized controlled trial is to compare the efficacy and safety of two epidural analgesia maintenance methods for labor pain relief: Programmed Intermittent Epidural Bolus (PIEB) and Continuous Epidural Infusion (CEI), both combined with Patient-Controlled Epidural Analgesia (PCEA). The study aims to evaluate which technique provides superior analgesia while minimizing anesthetic consumption and preserving maternal motor function. A total of 60 parturients at Family Hospital, Da Nang, will be randomly assigned to either the PIEB or CEI group. Outcomes including pain intensity (VAS scores), total drug consumption, maternal satisfaction, and neonatal Apgar scores will be assessed.
Eligibility
Inclusion Criteria7
- Parturients indicated for labor analgesia for vaginal delivery via epidural anesthesia.
- Age from 18 to 40 years.
- Physical status: ASA II.
- Singleton pregnancy, full-term, vertex presentation in labor.
- Indication for vaginal delivery.
- No contraindications to epidural anesthesia.
- Agreement to participate in the research and signed written informed consent.
Exclusion Criteria6
- Contraindications to epidural analgesia.
- History of allergy to local anesthetics (Ropivacaine) or opioids (Fentanyl).
- High-risk pregnancies: Preeclampsia, placenta previa, placental abruption.
- Fetal distress or fetal abnormalities.
- Chronic use of analgesic drugs or neurological/psychiatric disorders.
- Parturients who refuse to participate or request to withdraw from the research.
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Interventions
Initial dose: 10 mL (0.1% Ropivacaine + 2 mcg/mL Fentanyl). Maintenance: 8 mL bolus every 60 mins. PCEA: 5 mL bolus, 10-min lockout.
Initial dose: 10 mL (0.1% Ropivacaine + 2 mcg/mL Fentanyl). Maintenance: Continuous infusion at 8 mL/hour. PCEA: 5 mL bolus, 10-min lockout.
Locations(1)
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NCT07395934