The Effects of a 4-week Supplementation With a Ketogenic Nutrient Mix on 24-hour Substrate Metabolism and Muscle Health

This study investigates whether taking a ketogenic nutritional supplement each evening for 4 weeks — designed to induce a mild state of ketosis (fat-burning) overnight — can beneficially alter the 24-hour rhythm of energy metabolism in older, overweight adults with a sedentary lifestyle. Researchers will compare the effects of the ketogenic supplement against a non-ketogenic but equally caloric control supplement. Eligible participants are adults aged 60–80 years with a BMI of 25–35 kg/m², who are largely sedentary (less than 2 hours of structured exercise per week), have stable weight and sleep habits, and do not have type 2 diabetes, heart failure, severe organ insufficiency, or major disruptions to their circadian rhythm such as recent night shift work or international travel. Participation involves taking the assigned supplement daily in the evening for 4 weeks and attending research visits that include metabolic measurements and overnight monitoring. This summary was prepared using AI to help patients understand the study in plain language.