RecruitingPhase 4NCT07396441

Supplementary Kelulut Honey Therapy in Juvenile Open-Angle Glaucoma: Effects on IL-6, RNFL and Dry Eye

Supplementary Kelulut Honey Therapy in Juvenile Open-Angle Glaucoma: Effects on IL-6, RNFL and Dry Eye.


Sponsor

Universiti Sains Malaysia

Enrollment

60 participants

Start Date

Jan 15, 2026

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this clinical trial is to evaluate the effects of stingless bee honey (Kelulut honey) in juvenile open-angle glaucoma patients. The study evaluates the effects on serum Interleukin 6 level(IL-6), retinal nerve fiber layer(RNFL) thickness and dry eye-related symptoms. A total of 60 participants who meet the study criteria will be randomly assigned to one of two groups. One group will consume 30 grams of Kelulut honey daily for a period of three months, while the control group will not receive honey or a placebo. Serum IL-6 level, RNFL thickness, Tear break up time (TBUT) and Schirmer Test 1 will be done before and after 90 days. Adherence to honey consumption will be monitored using a daily diary. This study aims to provide better understanding of the potential role of Kelulut honey as a supplementary therapy in patients with juvenile open-angle glaucoma.


Eligibility

Min Age: 15 YearsMax Age: 40 Years

Plain Language Summary

Simplified for easier understanding

This study is investigating whether adding Kelulut honey — a type of stingless bee honey — alongside standard glaucoma treatment can reduce eye pressure, improve nerve fiber thickness in the eye, and relieve dry eye symptoms in young adults with juvenile open-angle glaucoma. **You may be eligible if...** - You are between 15 and 40 years old - You have been diagnosed with juvenile open-angle glaucoma - You are already following your regular glaucoma treatment and your eye pressure is at the target level **You may NOT be eligible if...** - You have a known allergy to honey or honey-based products - Your eye scan (OCT) quality is too low for accurate measurement - You have other retinal diseases or optic nerve conditions - You have a neurological disease affecting the whole body - You have serious health conditions such as diabetes, autoimmune disease, or are pregnant Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BIOLOGICALStingless bee honey (Kelulut)

Kelulut is stingless bee honey, a natural biologic product produced by stinglee bee species.


Locations(4)

Hospital Raja Perempuan Zainab II

Kota Bharu, Kelantan, Malaysia

Hospital Sultan Ismail Petra

Kuala Krai, Kelantan, Malaysia

Hospital Universiti Sains Malaysia

Kubang Kerian, Kelantan, Malaysia

Hospital Sultanah Nur Zahirah

Kuala Terengganu, Terengganu, Malaysia

View Full Details on ClinicalTrials.gov

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NCT07396441


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