Sodium-rich COndiments Unifying Health and Taste
Singapore Institute of Food and Biotechnology Innovation
32 participants
Sep 22, 2025
INTERVENTIONAL
Conditions
Summary
This research aims to develop an evidence-based classification for sodium-rich condiments (natremic index) based on their CVD-related risks. It is hypothesised that the acute cardiovascular and physiological response (effectively extrapolated to long-term CVD risks) to meals prepared with various sodium-rich condiments can be leveraged upon for the development of such an index that will systematically classify sodium-rich condiments based on the risk they present to cardiovascular health.
Eligibility
Inclusion Criteria7
- ≥ 50, \< 75 years old
- Male or postmenopausal female (self-reported)
- ≥ 50 kg body weight
- Systolic blood pressure (≥ 130, \< 160 mmHg) or diastolic blood pressure (≥ 85, \< 100 mmHg)
- Willing and able to follow intervention protocol
- Ability to identify basic tastes (determined by taste discrimination test)
- English speaking
Exclusion Criteria20
- Prescribed and taking medication which may affect study outcomes (i.e. for blood pressure management, blood thinning etc.) in consultation with study physician (Prof Melvin Leow) and PI(Dr Darel Toh)
- Type 1 or type 2 diabetes mellitus (i.e. fasting blood glucose ≥ 7.0 mmol/L or HbA1c ≥ 6.5 %)
- Taking dietary supplements which may affect study outcomes one month prior to their first visit in consultation with study physician, PI and study team
- Obesity (BMI ≥ 27.5 kg/m2)
- History or known present diagnosis of hematological (G6PD and coagulation disorders), hepatic (hepatitis B and C), renal, gastrointestional or other relevant disease / disorders which may affect the outcomes of interest in consultation with study physician, PI and study team
- History of arteriovenous shunt or mastectomy
- Women who are pregnant, lactating or planning pregnancy
- History or present diagnosis of HIV and/or tuberculosis
- History of severe vasovagal syncope (blackouts or near faints) following blood draw
- Drug abuse within last 5 years
- Excessive alcoholic beverage consumption \> 2 servings per day (1 serving defined as 360 mL beer, 150 mL wine or 45 mL distilled spirits)
- Smoking (cigarette, e-cigarette, cigar, pipe, vape)
- Engaging in habitual vigorous physical activity (as defined by physical activity questionnaire-PAR)
- Allergic or intolerance to intervention foods.
- Dislike or unwilling to consume intervention foods
- Photophobic (sensitivity to intense lights and colours), particularly to intense red lights
- Has sinus problems problems that affect taste and smell
- Involvement in other clinical studies that may influence the outcome of the study
- An ASTAR Staff.
- A study team member or their immediate family member
Interventions
To examine acute cardiovascular health response to plain porridge.
To examine acute cardiovascular health response to plain porridge with saltiness-matched light soya sauce
To examine acute cardiovascular health response to plain porridge with saltiness-matched fermented bean paste
To examine acute cardiovascular health response to plain porridge with saltiness-matched table salt.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT07397754