Cosiporfin Sodium for Injection Photodynamic Therapy

This study is testing a treatment called photodynamic therapy (PDT) using a drug called cosiporfin sodium — where a light-sensitive drug is injected into the body and then activated by a special light to destroy cancer cells — for patients with advanced bile duct cancer (cholangiocarcinoma) that cannot be surgically removed. **You may be eligible if...** - You are 18 or older - You have confirmed advanced or metastatic bile duct cancer outside the liver (extrahepatic cholangiocarcinoma) that is inoperable - You have not received prior chemotherapy or immunotherapy for advanced disease - You are in good functional health (ECOG 0 or 1) - You have at least one measurable tumor **You may NOT be eligible if...** - You have previously received photodynamic therapy or photosensitizing drugs - Your cancer has spread extensively to the liver (over 50% of liver affected) - You have brain metastases - You have active hepatitis B, C, HIV, or syphilis - You have serious heart, kidney, or blood clotting problems - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.