RecruitingNot ApplicableNCT07398495

Multimodal Training Effects in Middle-Aged and Older Adults With Diabetic Sarcopenia

Effects of Multimodal Training on Muscle Function and Glucose Metabolism in Middle-Aged and Older Adults With Type 2 Diabetes Mellitus and Sarcopenia

Sponsor

yueh chu wu

Enrollment

128 participants

Start Date

Feb 23, 2026

Study Type

INTERVENTIONAL

Conditions

Sarcopenia Type 2 Diabetes Mellitus (T2DM)

Summary

This study aims to investigate the effects of a 12-week multimodal exercise intervention on middle-aged and older adults (aged 45\~85 years) with Type 2 Diabetes Mellitus (T2DM). The program combines supervised training, home-based sessions, and digital support to improve muscle function, physical performance, metabolic control, and quality of life.

Eligibility

Min Age: 45 YearsMax Age: 85 Years

Inclusion Criteria5

Diagnosed with both Type 2 Diabetes Mellitus (T2DM) and sarcopenia.
Maintained on a stable regimen of oral hypoglycemic agents.
Aged 45 years or older.
Capable of communicating effectively in Mandarin or Taiwanese.
Willing to provide informed consent or have it obtained from a legally authorized representative.

Exclusion Criteria5

• Limited limb or joint function that prevents exercise (e.g., recent fractures or dislocations).
Communication barriers or severe emotional/psychological issues (e.g., uncontrolled depression or severe mental illness).
Severe cognitive impairment (e.g., dementia).
End-stage renal disease (ESRD).
Major comorbidities or complications, including active diabetic foot ulcers, amputation, recent myocardial infarction, severe autonomic neuropathy, or a history of stroke within the last 3 years.

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Interventions

BEHAVIORALMultimodal Exercise Program

Participants will engage in a 12-week multimodal exercise program comprising supervised training sessions, home-based exercises, and digital support. To facilitate adherence and proper technique, participants will also receive a "Diabetes and Muscle Health Handbook" as a training guide.