Type 2 Diabetes Mellitus (T2DM) Clinical Trials

62 recruiting

Type 2 Diabetes Mellitus (T2DM) Trials at a Glance

65 actively recruiting trials for type 2 diabetes mellitus (t2dm) are listed on ClinicalTrialsFinder across 6 cities in 29 countries. The largest study group is Not Applicable with 31 trials, with the heaviest enrollment activity in Seoul, Philadelphia, and Birmingham. Lead sponsors running type 2 diabetes mellitus (t2dm) studies include BrightGene Bio-Medical Technology Co., Ltd., Alnylam Pharmaceuticals, and Duke University.

Browse type 2 diabetes mellitus (t2dm) trials by phase

Treatments under study

About Type 2 Diabetes Mellitus (T2DM) Clinical Trials

Looking for clinical trials for Type 2 Diabetes Mellitus (T2DM)? There are currently 62 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Type 2 Diabetes Mellitus (T2DM) trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Type 2 Diabetes Mellitus (T2DM) clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 65 trials

Recruiting
Phase 4

Effect of Early Combination Antihyperglycemic Treatment on Metabolic Control in Individuals With Type 2 Diabetes

Type 2 Diabetes Mellitus (T2DM)
University Medical Centre Ljubljana90 enrolled1 locationNCT06613854
Recruiting

Optimization and Evaluation of the Diagnosis and Treatment System for Diabetic Retinopathy in Type 2 Diabetes Mellitus

DiabetesType 2 Diabetes Mellitus (T2DM)Diabetic Retinopathy
Yufan Wang2,920 enrolled3 locationsNCT06821399
Recruiting
Phase 1Phase 2

A Study to Evaluate ALN-4324 in Overweight to Obese Healthy Volunteers and in Overweight to Obese Patients With T2DM

Type 2 Diabetes Mellitus (T2DM)Obese or Overweight Healthy Volunteers
Alnylam Pharmaceuticals144 enrolled20 locationsNCT06845202
Recruiting
Phase 2

A Study to Evaluate ALN-4324 on Insulin Sensitivity in Adults With Type 2 Diabetes Mellitus

Type 2 Diabetes Mellitus (T2DM)
Alnylam Pharmaceuticals40 enrolled1 locationNCT07465224
Recruiting
Phase 1

Phase I Study to Evaluate the Pharmacokinetics and Safety After Co-administration of L03RD1 and L03RD2 or Administration of L03TD1 in Healthy Volunteers

Type 2 Diabetes Mellitus (T2DM)
Celltrion48 enrolled1 locationNCT07533539
Recruiting
Not Applicable

Implementation pRogram to Improve Screening and Management for CKD in Diabetes (Program 1) (IRIS-CKD)

Type 2 Diabetes Mellitus (T2DM)Chronic Kidney Disease(CKD)Type 2 DM
Duke University750 enrolled6 locationsNCT06906627
Recruiting
Not Applicable

Implementation pRogram to Improve Screening and Management for CKD in Diabetes (IRIS-CKD) (Program 2)

Type 2 Diabetes Mellitus (T2DM)Chronic Kidney Disease(CKD)Type 2 DM
Duke University420 enrolled6 locationsNCT06906640
Recruiting

Assessment of Pancreatic Dysfunction in Patients With Type 2 Diabetes

Type 2 Diabetes Mellitus (T2DM)Exocrine Pancreatic Insufficiency (EPI)Pancreatogenic Diabetes Mellitus
West Kazakhstan Marat Ospanov Medical University310 enrolled1 locationNCT07512934
Recruiting
Phase 4

The Impact of Semaglutide Compared to Energy Restriction on Type 2 Diabetes

Type 2 Diabetes Mellitus (T2DM)SemaglutideCaloric Restriction
Second Affiliated Hospital of Nanchang University100 enrolled1 locationNCT07272343
Recruiting
Not Applicable

Multimodal Training Effects in Middle-Aged and Older Adults With Diabetic Sarcopenia

SarcopeniaType 2 Diabetes Mellitus (T2DM)
yueh chu wu128 enrolled1 locationNCT07398495
Recruiting
Not Applicable

Groceries Plus Multi-Component Lifestyle Intervention for Adults With Hypertension and Type 2 Diabetes

HypertensionType 2 Diabetes Mellitus (T2DM)
Johns Hopkins University80 enrolled1 locationNCT06921356
Recruiting
Not Applicable

Feasibility of a Tailored Online Self-compassion Intervention

Type 2 Diabetes Mellitus (T2DM)Type 1 Diabetes Mellitus
Canterbury Christ Church University50 enrolled2 locationsNCT07051005
Recruiting

Polyphenol Metabotypes in People With Diabetes Type 2

Type 2 Diabetes Mellitus (T2DM)
University Hospital, Ghent100 enrolled2 locationsNCT06810635
Recruiting
Not Applicable

Using Continuous Glucose Monitoring to Quantify the Effects of NOURISH's Culturally Modified Meals on Asian Americans With Type 2 Diabetes

Type 2 Diabetes Mellitus (T2DM)Type 2 Diabetes
Stanford University30 enrolled1 locationNCT06836479
Recruiting
Phase 1

A Study of REGEND003 on Patients With Type 2 Diabetes Mellitus (T2DM) and Chronic Kidney Disease (CKD)

Type 2 Diabetes Mellitus (T2DM) and Chronic Kidney Disease (CKD)
Regend Therapeutics15 enrolled1 locationNCT07275788
Recruiting

Investigation of Motor Imagery Ability, Body Awareness and Cognitive Functions in Type 2 Diabetes Mellitus

Cognitive FunctionType 2 Diabetes Mellitus (T2DM)Motor İmagery Ability
Kutahya Health Sciences University100 enrolled1 locationNCT06588894
Recruiting
Not Applicable

Achieving Routine Intervention and Screening for Emotional Health

Type 2 Diabetes Mellitus (T2DM)Diabetes Distress
University of Chicago1,250 enrolled1 locationNCT06887049
Recruiting
Not Applicable

Continuous Glucose Monitoring for Outpatient Diabetes Management After Hospital Discharge

Type 1 Diabetes Mellitus (T1DM)Type 2 Diabetes Mellitus (T2DM)Hyperglycemia
Vanderbilt University Medical Center60 enrolled1 locationNCT06852950
Recruiting
Phase 4

Glycemic Variability of Combination Therapies in T2DM

Type 2 Diabetes Mellitus (T2DM)
JW Pharmaceutical178 enrolled1 locationNCT07442006
Recruiting
Not Applicable

Para-Probiotic Oral Care in Periodontal Patients With Type 2 Diabetes

Type 2 Diabetes Mellitus (T2DM)Periodontitis
University of Pavia40 enrolled1 locationNCT07069166