Type 2 Diabetes Mellitus (T2DM) Clinical Trials

76 recruitingLast updated: June 17, 2026

There are 76 actively recruiting type 2 diabetes mellitus (t2dm) clinical trials across 32 countries. Studies span Not Applicable, Phase 2, Phase 1, Phase 4, Phase 3. Top locations include Philadelphia, Pennsylvania, United States, Seoul, South Korea, Birmingham, Alabama, United States. Updated daily from ClinicalTrials.gov.


Type 2 Diabetes Mellitus (T2DM) Trials at a Glance

76 actively recruiting trials for type 2 diabetes mellitus (t2dm) are listed on ClinicalTrialsFinder across 6 cities in 32 countries. The largest study group is Not Applicable with 37 trials, with the heaviest enrollment activity in Philadelphia, Seoul, and Birmingham. Lead sponsors running type 2 diabetes mellitus (t2dm) studies include BrightGene Bio-Medical Technology Co., Ltd., Alnylam Pharmaceuticals, and Duke University.

Browse type 2 diabetes mellitus (t2dm) trials by phase

Treatments under study

About Type 2 Diabetes Mellitus (T2DM) Clinical Trials

Looking for clinical trials for Type 2 Diabetes Mellitus (T2DM)? There are currently 73 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Type 2 Diabetes Mellitus (T2DM) trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Type 2 Diabetes Mellitus (T2DM) clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 76 trials

Recruiting
Not Applicable

Implementation pRogram to Improve Screening and Management for CKD in Diabetes (Program 1) (IRIS-CKD)

Type 2 Diabetes Mellitus (T2DM)Chronic Kidney Disease(CKD)Type 2 DM
Duke University750 enrolled7 locationsNCT06906627
Recruiting
Not Applicable

Implementation pRogram to Improve Screening and Management for CKD in Diabetes (IRIS-CKD) (Program 2)

Type 2 Diabetes Mellitus (T2DM)Chronic Kidney Disease(CKD)Type 2 DM
Duke University420 enrolled7 locationsNCT06906640
Recruiting

Validity and Reliability of Mixed Reality-Based Functional Mobility Tests in Type 2 Diabetes

Type 2 Diabetes Mellitus (T2DM)
Selcuk University75 enrolled1 locationNCT07649967
Recruiting
Not Applicable

The Cognitive Protective Effect of VR-based Cognitive Training in Type 2 Diabetes Patients With Mild Cognitive Impairment

Type 2 Diabetes Mellitus (T2DM)Mild Cognitive Impairment (MCI)
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School40 enrolled1 locationNCT07650318
Recruiting
Phase 1Phase 2

A Study to Evaluate ALN-4324 in Overweight to Obese Healthy Volunteers and in Overweight to Obese Patients With T2DM

Type 2 Diabetes Mellitus (T2DM)Obese or Overweight Healthy Volunteers
Alnylam Pharmaceuticals144 enrolled22 locationsNCT06845202
Recruiting
Phase 2

A Study to Evaluate ALN-4324 on Insulin Sensitivity in Adults With Type 2 Diabetes Mellitus

Type 2 Diabetes Mellitus (T2DM)
Alnylam Pharmaceuticals40 enrolled1 locationNCT07465224
Recruiting
Not Applicable

Achieving Routine Intervention and Screening for Emotional Health

Type 2 Diabetes Mellitus (T2DM)Diabetes Distress
University of Chicago1,250 enrolled1 locationNCT06887049
Recruiting

Diagnostic Value of the Liver Inflammation Index for MASH in Patients With T2DM and MAFLD

Type 2 Diabetes Mellitus (T2DM)MASH - Metabolic Dysfunction-Associated SteatohepatitisMetabolic Dysfunction-associated Fatty Liver Disease
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School10,000 enrolled22 locationsNCT07632677
Recruiting
Phase 4

SGLT2 Inhibitors on Coronary Atherosclerosis Progression Via Perivascular Adipose Tissue in Diabetes

AtherosclerosisType 2 Diabetes Mellitus (T2DM)Coronary Artery Disease
Junjie Yang144 enrolled2 locationsNCT07614230
Recruiting

The Effect of Local Corticosteroid Injection in Carpal Tunnel Syndrome Patients With Type 2 Diabetes

Type 2 Diabetes Mellitus (T2DM)Carpal Tunnel Syndrome (CTS)
Haydarpasa Numune Training and Research Hospital60 enrolled1 locationNCT07433257
Recruiting

Fitbit and AI Chatbot in Sedentary Primary Care Patients With T2D

Type 2 Diabetes Mellitus (T2DM)Type 2 DiabetesT2DM+4 more
University of Colorado, Denver36 enrolled1 locationNCT07005362
Recruiting
Not Applicable

The GRoceries Aimed at Increasing Nutrition Study

Type 2 Diabetes Mellitus (T2DM)Type 2 DiabetesType 2 Diabetes (T2DM)+6 more
University of Pennsylvania216 enrolled1 locationNCT07167004
Recruiting
Not Applicable

Effects of Short and Long Courses of Intermittent Hypoxic-Hyperoxic Training in Patients With Type 2 Diabetes Including Elderly

Metabolic SyndromeType 2 Diabetes Mellitus (T2DM)Older Adults (65 Years and Older)+1 more
National Medical Research Center for Therapy and Preventive Medicine250 enrolled1 locationNCT07574333
Recruiting
Not Applicable

The Transit Bipartition With the Use of a Metallic Anastomosis Clip and Circular Fundocorporeal Gastroplication

Obesity, OverweightType 2 Diabetes Mellitus (T2DM)Leakage, Anastomotic+1 more
The Society of Bariatric and Metabolic Surgeons of Kazakhstan90 enrolled1 locationNCT07495020
Recruiting

Function of Beta Cells in Early-onset Diabetes Mellitus

Type 2 Diabetes Mellitus (T2DM)Beta Cell Function
University Medical Center Ho Chi Minh City (UMC)296 enrolled1 locationNCT07574138
Recruiting
Not Applicable

Effectiveness of and Implementation Strategies for 'Disfrutando'.

Type 2 Diabetes Mellitus (T2DM)
University of Missouri-Columbia31 enrolled2 locationsNCT07023406
Recruiting
Phase 4

Effect of Early Combination Antihyperglycemic Treatment on Metabolic Control in Individuals With Type 2 Diabetes

Type 2 Diabetes Mellitus (T2DM)
University Medical Centre Ljubljana90 enrolled1 locationNCT06613854
Recruiting

Optimization and Evaluation of the Diagnosis and Treatment System for Diabetic Retinopathy in Type 2 Diabetes Mellitus

DiabetesType 2 Diabetes Mellitus (T2DM)Diabetic Retinopathy
Yufan Wang2,920 enrolled3 locationsNCT06821399
Recruiting
Phase 1

Phase I Study to Evaluate the Pharmacokinetics and Safety After Co-administration of L03RD1 and L03RD2 or Administration of L03TD1 in Healthy Volunteers

Type 2 Diabetes Mellitus (T2DM)
Celltrion48 enrolled1 locationNCT07533539
Recruiting

Assessment of Pancreatic Dysfunction in Patients With Type 2 Diabetes

Type 2 Diabetes Mellitus (T2DM)Exocrine Pancreatic Insufficiency (EPI)Pancreatogenic Diabetes Mellitus
West Kazakhstan Marat Ospanov Medical University310 enrolled1 locationNCT07512934