RecruitingEarly Phase 1NCT07400471

The Effects of Preemptive Multimodal Analgesic on Endodontic Pain Following Root Canal Therapy.

The Effects of Preemptive Multimodal Analgesic on Endodontic Pain.

Sponsor

Chattogram International Dental College

Enrollment

280 participants

Start Date

Feb 6, 2026

Study Type

INTERVENTIONAL

Conditions

Post-endodontic Pain Mechanical Detection Threshold Mechanical Pain Threshold Mechanical Pain Sensitivity

Summary

A clinical trial comparing preemptive multimodal analgesics with placebo in the management of immediate and chronic post-endodontic pain. The study utilizes statistical methods such as chi-squared, T-tests, and regression analysis, accounting for multiple outcomes with the Bonferroni adjustment. Duloxetine hydrochloride and pregabalin, both available in Bangladesh, are evaluated as experimental drugs, while placebos are used to assess psychological effects on pain. All participants receive standard interventional treatments, with acetaminophen provided as needed, and ethical considerations are addressed according to international guidelines.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Duloxetine- Acetaminophen and a drug called Pregabalin- Acetaminophen for people with mechanical detection threshold, mechanical pain sensitivity, and other related conditions. The study is currently recruiting participants at 1 location. People eligible for this study include aged 18 Years and older.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGPregabalin- Acetaminophen

Preemptive Multi modal analgesic drug: Experimental group will be divided into 2 subgroups according to use of drug. A. Pregabalin-acetaminophen. B. Duloxetine-Acetaminophen Pregabalin-acetaminophen: Before a half-hour endodontic treatment, patients in this group will receive a single dosage of 50 mg pregabalin and 500 mg acetaminophen. If necessary, acetaminophen dosages of 500 mg will be administered three times a day.

DRUGDuloxetine- Acetaminophen

Duloxetine-Acetaminophen: Prior to a half-hour endodontic treatment, patients in this group will receive a single dosage of 500 mg of acetaminophen and 30 mg of Duloxetine. If necessary, acetaminophen dosages of 500 mg will be administered three times a day.

Locations(1)

Professor. Dr. Md. Abu Saeed Ibn Harun

Chittagong, Chattogram, Bangladesh

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NCT07400471

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