RecruitingNot ApplicableNCT07411391

Supervised Endoscopic Tele-controlled Intelligent Lithotripsy

A Feasibility Trial of a Novel Robotic System for Retrograde Intrarenal Surgery

Sponsor

Chinese University of Hong Kong

Enrollment

15 participants

Start Date

Feb 15, 2026

Study Type

INTERVENTIONAL

Conditions

Renal Stone

Summary

This is a phase I feasibility study to investigate the use of a novel intelligent robotic retrograde intrarenal surgery (RIRS) platform. The TaloStone T1000 RIRS system can manipulate the flexible ureteroscope, with remote control of the instruments (laser fibre or basket) and ureteral access sheath movements. Beyond teleoperation, the TaloStone T1000 RIRS system integrates AI perception models and decision-making algorithms to enable the supervised autonomous execution of critical tasks within the RIRS workflow.

Eligibility

Min Age: 19 Years

Inclusion Criteria4

Adult patients >18 years old
Renal stone(s) less than 1cm 2cm in maximal length
Clinically indicated for RIRS
Willingness to participate as demonstrated by giving informed consent

Exclusion Criteria8

Patients with no preoperative CT imaging available
Patients who are not recommended to receive RIRS
Severe concomitant illness that drastically shortens life expectancy or increases risk of therapeutic intervention
Untreated active infection
Un-corrected coagulopathy
Presence of another malignancy or distant metastasis
Emergency surgery
Vulnerable population (e.g. mentally disabled, pregnant)

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Interventions

PROCEDURERIRS using the TaloStone T1000 RIRS platform

Retrograde intrarenal surgery (RIRS) will be performed using the TaloStone T1000 RIRS system. Beyond teleoperation, the TaloStone T1000 RIRS system integrates advanced AI perception models and decision-making algorithms to enable the autonomous execution of critical tasks within the RIRS workflow. The AI-based vision models coupled with sensors in the fURS allow real-time scene understanding, depth perception, stone size estimation, pressure and temperature feedback, and object tracking - thus establishing a robust foundation for higher level of surgical autonomy. Under supervision by the surgeon, the TaloStone T1000 RIRS system can perform supervised navigation into the collecting system, actively track a target stone, dynamically target the laser fibre tip towards a stone, plan the laser fragmentation route, and perform scope withdrawal for stone suction with re-entry.