RecruitingNCT07414056
Turning Ratios Into Prognosis: Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios as Powerful Predictors of ARDS in Pediatric Burn Patients: A Prospective Evaluation
Sponsor
Ain Shams University
Enrollment
60 participants
Start Date
Nov 10, 2025
Study Type
OBSERVATIONAL
Conditions
Summary
The aim of this study is to evaluate the role of Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios as predictors for development of ARDS in pediatric burn patients.
Eligibility
Min Age: 1 YearMax Age: 12 Years
Inclusion Criteria5
- Age 1-12 years.
- Patients presenting within 24 hours of burn injury.
- Patients presenting with severe burns 20-40% of total body surface area (TBSA).
- Thermal burns or scalds.
- Both sexes.
Exclusion Criteria12
- Patient refusal to participate in the trial.
- Age \<1 \& \>12 years.
- Delayed admission \>24h post-injury.
- Patients presenting with burns \<20% or \>40% of TBSA.
- Non-thermal burns.
- Associated medical comorbidities: Chronic liver or kidney diseases, anemia.
- Preexisting chronic lung disease (e.g., cystic fibrosis, severe bronchopulmonary dysplasia).
- Inflammatory conditions (e.g., inflammatory bowel disease).
- Immunocompromised individuals, autoimmune diseases, those undergoing treatment with immunosuppressants, corticosteroids, cytotoxic chemotherapy.
- Known malignancies, hematologic malignancy or conditions altering WBC/platelets significantly.
- Previous malnutrition.
- Immunosuppressive therapy prior to admission (e.g., chronic steroids).
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Interventions
DIAGNOSTIC_TESTNeutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios
Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios as Powerful Predictors of ARDS in Pediatric Burn Patients
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT07414056
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