Improving LDL-C Levels Through Temporal Self-regulation Theory-based, Personality-tailored Health Messages: A Three-Arm Randomized Controlled Trial
National University Health System, Singapore
3,000 participants
Nov 25, 2025
INTERVENTIONAL
Conditions
Summary
The study is meant to run parallel to the larger study, RESET. The goal of this study is to to evaluate the effectiveness of a once-off general and personality-tailored text message on GP consultation among RESET participants identified to have high LDL-C. The main question it aims to answer is: Will participants exposed to personality tailored advice have a higher adherence to GP consultation compared to the participants in the control group? Researchers will compare a personalized message to a general message (with no personalization according to patients personality type) and control group to see if drug the messages increase adherence. Participants are required to complete two questionnaires: one before and one after they receive their RESET results.
Eligibility
Inclusion Criteria2
- New participants of RESET who have given consent to be contacted for future studies
- ≥21 years old
Exclusion Criteria1
- are not able to read, write or communicate in English
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Interventions
The intervention will consist of messages and infographics embedded in participants' return of results (ROR) emails within the RESET study. Each participant will receive the ROR alongside the intervention once, at the time their results are sent. No repeat messages will be delivered. The general health message will include indications for lipid therapy, benefits of lipid-lowering medications, common side effects, risks of non-adherence, and an infographic on diet and lifestyle modification based on ACE lipid management guidance. The infographic will be included in the same ROR email.
The intervention will consist of messages and infographics embedded in participants' return of results (ROR) emails within the RESET study. Each participant will receive the ROR alongside the intervention once, at the time their results are sent. No repeat messages will be delivered. The message will include the personality-tailored message with the same core content as the general message, including indications for lipid therapy, benefits of lipid-lowering medications, common side effects, risks of non-adherence, and an infographic on diet and lifestyle modification based on ACE lipid management guidance. An infographic will be included in the same ROR email. This message will contain an added component framed according to conscientiousness and neuroticism scores, as these traits are strong predictors of health behaviours. Scores will be derived from baseline BFI-44 results.
Locations(1)
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NCT07415109