RecruitingNot ApplicableNCT07415720

Artichoke By-products Rich in Hydroxycinnamic Acids and Mediterranean Diet for Type 2 Diabetes Prevention.

Multiomic Evaluation of the Effect of Artichoke By-products Supplementation Rich in Hydroxycinnamic Acids, Integrated Into an Energy-restricted Mediterranean Diet, on the Prevention of Type 2 Diabetes.

Sponsor

Clinica Universidad de Navarra, Universidad de Navarra

Enrollment

150 participants

Start Date

May 1, 2026

Study Type

INTERVENTIONAL

Conditions

Diabete Type 2

Summary

The ARTI-UP study evaluates whether daily consumption of a supplement made from artichoke by-products, rich in hydroxycinnamic acids (HCAs), in combination with an energy-restricted Mediterranean diet (erMeDiet), can improve glycaemic control, reduce insulin resistance and contribute to weight loss in subjects with overweight or obesity. In addition, it seeks to understand the biological mechanisms involved using omic techniques and to establish predictive biomarkers that will enable progress towards personalised nutrition strategies.

Eligibility

Min Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This study looks at whether consuming artichoke by-products (which are rich in beneficial plant compounds called hydroxycinnamic acids) alongside a Mediterranean diet can help prevent type 2 diabetes in people who are overweight and have early signs of insulin resistance. **You may be eligible if...** - Your BMI is between 25 and 35 kg/m² - You have a HOMA-IR score of 2.5 or higher (a marker of insulin resistance) - You are in generally good health - You are willing to sign informed consent **You may NOT be eligible if...** - You are already diagnosed with type 2 diabetes - You have other significant health conditions unrelated to metabolic health Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

DIETARY_SUPPLEMENTArtichoke by-product capsules

The intervention group will consume artichoke by-product capsules for 16 weeks.

BEHAVIORALEnergy-restricted Mediterranean diet (erMeDiet)

All study participants will follow an energy-restricted Mediterranean diet (erMeDiet) for 16 weeks.

DIETARY_SUPPLEMENTPlacebo capsules

The control group will consume placebo capsules for 16 weeks.

BEHAVIORALPhysical activity

Participants will receive a recommendation to engage in physical activity (at least 150 minutes/week of moderate physical activity) for 16 weeks.

Locations(1)

University of Navarra

Pamplona, Navarre, Spain

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT07415720

Related Trials

Role of Endothelial Progenitor Cells Dysregulation and Inflammation in the Pathophysiology of Cardiovascular Complications of Type 2 Diabetes

NCT075564971 location

Clinical Trial to Evaluate the Efficacy and Safety of Monotherapy Group of HL1113R1 or HL1113R2 Versus HL1113 (Fixed Dose Combination) in Patients With Essential Hypertension and Type II Diabetes Mellitus

NCT075523891 location

Investigation of Gastric Emptying by Gastric Ultrasonography in Diabetic Patients Treated With GLP-1 Receptors

NCT075063561 location

Magnetic Compression Anastomosis Procedure for Partial Jejunoileal Anastomosis: Assessing the Viability of an Innovative Metabolic Approach

NCT074957871 location

Brain Blood Flow and Sugar Transport in Alzheimer's Disease With and Without Diabetes - A Pilot Imaging Study

NCT074820721 location