RecruitingPhase 1NCT07416695

A Phase I Clinical Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of HLX3901 in Patients With Advanced SCLC or NEC

A Phase I Clinical Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of HLX3901 (DLL3 × DLL3 × CD3 × CD28 Tetra-specific Antibody) in Patients With Advanced Small Cell Lung Cancer or Neuroendocrine Carcinoma


Sponsor

Shanghai Henlius Biotech

Enrollment

138 participants

Start Date

Apr 17, 2026

Study Type

INTERVENTIONAL

Conditions

Summary

This study is an open-label first-in-human phase I clinical study to evaluate the safety, tolerability, and pharmacokinetic characteristics of HLX3901 in patients with Advanced Small Cell Lung Cancer or Neuroendocrine Carcinoma.


Eligibility

Min Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called HLX3901 for people with nec and sclc. The study is currently recruiting participants at 2 locations. People eligible for this study include aged 18 Years to 75 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGHLX3901

• HLX3901 will be administered as an intravenous (IV) infusion.


Locations(2)

Peking Union Medical College Hospital

Beijing, China

Shanghai Chest Hospital

Shanghai, China

View Full Details on ClinicalTrials.gov

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NCT07416695


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