RecruitingNCT07416760

Analysis of the Composition of the Intestinal Microbiota in Patients Post-intestinal Anastomosis

Analysis of the Composition of the Intestinal Microbiota and Its Evolution in Patients Post-intestinal Anastomosis


Sponsor

Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz

Enrollment

30 participants

Start Date

Feb 14, 2026

Study Type

OBSERVATIONAL

Summary

Recent research suggests a significant link between gut microbiota and anastomotic leakage (AL) in colorectal surgery. Patients who develop AL have a higher abundance of bacteria from the Lachnospiraceae family and lower microbial diversity. Considering the bibliographic data, our main interest is to analyze the microbial population of patients in our social environment and then look for differences in the microbiome between those who have suffered an anastomotic dehiscence (around 8-9% according to the results of our hospital's Surgery Department) and those who have not.


Eligibility

Min Age: 18 Years

Inclusion Criteria4

  • Patients who have undergone colorectal intestinal anastomosis.
  • Signing of the informed consent form.
  • Age ≥18 years with good functional status.
  • Availability for postoperative follow-up.

Exclusion Criteria5

  • Emergency surgery.
  • Intra-abdominal sepsis or previous dehiscence.
  • Severe immunosuppression.
  • Use of antibiotics in the 3 months prior to preoperative preparation.
  • Pregnancy or breastfeeding.

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Interventions

OTHERNot applicable- observational study

Fecal sample collection


Locations(1)

University Hospital Fundación Jiménez Díaz

Madrid, Spain

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NCT07416760