Analysis of the Composition of the Intestinal Microbiota in Patients Post-intestinal Anastomosis
Analysis of the Composition of the Intestinal Microbiota and Its Evolution in Patients Post-intestinal Anastomosis
Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz
30 participants
Feb 14, 2026
OBSERVATIONAL
Summary
Recent research suggests a significant link between gut microbiota and anastomotic leakage (AL) in colorectal surgery. Patients who develop AL have a higher abundance of bacteria from the Lachnospiraceae family and lower microbial diversity. Considering the bibliographic data, our main interest is to analyze the microbial population of patients in our social environment and then look for differences in the microbiome between those who have suffered an anastomotic dehiscence (around 8-9% according to the results of our hospital's Surgery Department) and those who have not.
Eligibility
Inclusion Criteria4
- Patients who have undergone colorectal intestinal anastomosis.
- Signing of the informed consent form.
- Age ≥18 years with good functional status.
- Availability for postoperative follow-up.
Exclusion Criteria5
- Emergency surgery.
- Intra-abdominal sepsis or previous dehiscence.
- Severe immunosuppression.
- Use of antibiotics in the 3 months prior to preoperative preparation.
- Pregnancy or breastfeeding.
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Interventions
Fecal sample collection
Locations(1)
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NCT07416760