Comparing the Extent to Which Two Evolocumab Drug Products Are Made Available in the Body After a Single Subcutaneous Dose

Exclusion Criteria8

• History or evidence of any clinically significant disorder, condition, or disease that in the opinion of the investigator (or designee) would pose a risk to participant safety or interfere with the trial evaluation, procedures, or completion.
• History or current signs or symptoms of cardiovascular disease.
• History or evidence of clinically significant arrhythmia.
• History of hypersensitivity, intolerance, or allergy to evolocumab or its ingredients or other biological drugs.
• Uncontrolled hyperthyroidism or hypothyroidism.
• Current use or prior use of over-the-counter or other prescription medications, herbal medicines, vitamins, and supplements within 30 days or 5 half-lives prior to check-in.
• Participation in another investigational device or drug trial within the past 30 days or 5 half-lives prior to check-in.
• Have previously completed or withdrawn from this trial or any other trial investigating evolocumab, any other product directed against PCSK9, or have previously received evolocumab or PCSK9 inhibitor.