RecruitingPhase 2NCT07423585

Tarlatamab for the Treatment of Extensive Stage Small-cell Lung Cancer

A Front-Line Window-of-Opportunity Phase 2 Study of Tarlatamab (Bispecific T Cell Engager: DLL3-CD3) in Patients With Extensive-Stage Small-Cell Lung Cancer


Sponsor

Asrar Alahmadi

Enrollment

39 participants

Start Date

Apr 1, 2026

Study Type

INTERVENTIONAL

Conditions

Summary

This phase II trial tests the effect of tarlatamab in treating patients with small cell lung cancer (SCLC) that has spread from where it first started to other parts of the body (extensive-stage). SCLC is an aggressive cancer which has a low 5-year survival rate. Tarlatamab is a bispecific antibody that can bind to two different antigens at the same time. Tarlatamab binds to DLL3 which is a protein found on the surface of some types of tumor cells, including small-cell lung cancer, and to CD3 which is present on immune system T-cells (a type of white blood cell) and may interfere with the ability of tumor cells to grow and spread. This may increase the length of time to progression (growing, spreading, or getting worse) and help patients with extensive-stage SCLC live longer.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a drug called tarlatamab for people with extensive-stage small cell lung cancer (a type of aggressive lung cancer that has spread). Tarlatamab is a new type of cancer therapy designed to help the immune system find and attack cancer cells. **You may be eligible if...** - You are 18 years old or older - You have been newly diagnosed with extensive-stage small cell lung cancer, or you had limited-stage disease that came back more than 6 months after treatment - You are in good enough health to participate (ECOG performance status 0–2) **You may NOT be eligible if...** - Your cancer has not been confirmed by a pathology test (tissue or cell sample) - You are not well enough to tolerate treatment - You are under 18 years old Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDUREBiopsy Procedure

Undergo biopsies

PROCEDUREBiospecimen Collection

Undergo blood sample collection

PROCEDUREComputed Tomography

Undergo computed tomography

PROCEDUREEchocardiography Test

Undergo ECHO

OTHERElectronic Health Record Review

Ancillary studies

PROCEDUREMagnetic Resonance Imaging

Undergo MRI

PROCEDUREMultigated Acquisition Scan

Undergo MUGA

OTHERQuestionnaire Administration

Ancillary studies

DRUGTarlatamab

Given IV


Locations(1)

Ohio State University Comprehensive Cancer Center

Columbus, Ohio, United States

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NCT07423585


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