RecruitingPhase 1NCT07425483

CAR-NK Cells (CL-NK-003) in Pancreatic Cancer

A Clinical Study of CAR-NK Cells (CL-NK-003) in Patients With Advanced Pancreatic Cancer


Sponsor

Changhai Hospital

Enrollment

9 participants

Start Date

Feb 12, 2026

Study Type

INTERVENTIONAL

Conditions

Summary

This is a single-center, open-label, first-in-human, fixed-dose study in patients with pancreatic cancer.


Eligibility

Min Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a new type of cancer treatment called CAR-NK cell therapy (CL-NK-003) for people with advanced or recurrent pancreatic cancer. CAR-NK cells are immune cells that have been engineered in a laboratory to recognise and attack cancer cells. **You may be eligible if...** - You are between 18 and 75 years old - You have locally advanced, metastatic, or recurrent pancreatic cancer - Your tumor shows a specific protein (eGR1) detected on at least 40% of cancer cells - Standard treatments have failed, were not tolerated, or were declined - You have at least one measurable area of cancer - You are in reasonably good health (ECOG performance status 0–2) - Your life expectancy is more than 12 weeks **You may NOT be eligible if...** - Your tumor does not express the eGR1 protein at the required level - You have received anti-cancer treatment within the past 4 weeks - Your blood counts or organ function are below the required thresholds Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BIOLOGICALCL-NK-003

Fixed-dose (3 × 10\^9 cells)


Locations(1)

Changhai Hospital

Shanghai, China

View Full Details on ClinicalTrials.gov

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NCT07425483


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