RecruitingPhase 1NCT07425483
CAR-NK Cells (CL-NK-003) in Pancreatic Cancer
A Clinical Study of CAR-NK Cells (CL-NK-003) in Patients With Advanced Pancreatic Cancer
Sponsor
Changhai Hospital
Enrollment
9 participants
Start Date
Feb 12, 2026
Study Type
INTERVENTIONAL
Conditions
Summary
This is a single-center, open-label, first-in-human, fixed-dose study in patients with pancreatic cancer.
Eligibility
Min Age: 18 YearsMax Age: 75 Years
Plain Language Summary
Simplified for easier understanding
This study is testing a new type of cancer treatment called CAR-NK cell therapy (CL-NK-003) for people with advanced or recurrent pancreatic cancer. CAR-NK cells are immune cells that have been engineered in a laboratory to recognise and attack cancer cells.
**You may be eligible if...**
- You are between 18 and 75 years old
- You have locally advanced, metastatic, or recurrent pancreatic cancer
- Your tumor shows a specific protein (eGR1) detected on at least 40% of cancer cells
- Standard treatments have failed, were not tolerated, or were declined
- You have at least one measurable area of cancer
- You are in reasonably good health (ECOG performance status 0–2)
- Your life expectancy is more than 12 weeks
**You may NOT be eligible if...**
- Your tumor does not express the eGR1 protein at the required level
- You have received anti-cancer treatment within the past 4 weeks
- Your blood counts or organ function are below the required thresholds
Talk to your doctor to see if this trial is right for you.
This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.
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Interventions
BIOLOGICALCL-NK-003
Fixed-dose (3 × 10\^9 cells)
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT07425483
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